Toxno Substance Profile
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Substance Name

Diflubenzuron
Identification Number: CASRN | 35367-38-5

  Substance Attributes


  • Metabolic Interference or Disruption

    Interferes with human metabolism. This can be a very serious thing. Some of these interference mechanics are well established. However, often long term effects and health consequences remain largely unknown. Additionally an emerging area of concern and one that is not currently studied, is the combined synergistic effects these metabolically disrupting chemicals have on human health.


    Metabolic interference happens when the substance produces highly reactive and often damaging intermediates during detoxification or when the substance binds to specific enzymes, important structural groups on molecules, receptors and membranes or targets DNA or mimics key nutrients.

  • Toxic to Bees

    Bees pollinate plants. No pollination no plants. No plants no food. We go hungry or starve.

These attributes are ONLY based on peer-reviewed evidence. See link to Data Sources below. Everyone benefits from knowing this stuff. Please Share.



  • CATEGORIES: Pesticide | Food Toxin | Synthetic Toxin | PESTICIDE active ingredient | organic | insecticide | chemosterilants | Pesticide or Plant Growth Regulator Approved in Australia | Pesticide approved in USA (California) | Pesticide approved or pending approval in EU | Slightly Toxic and Dangerous to Bees. Currently used in USA as a pesticide
  • SUBSTANCE LINEAGE: Organic Compounds | Benzenoids | Benzene and Substituted Derivatives | N-Phenylureas | N-Acyl Phenylureas
  • SYNONYMS: 1-(4-Chlorophenyl)-3-(2,6-difluorobenzoyl)urea | 1-(p-Chlorophenyl)-3-(2,6-difluorobenzoyl)-Urea | 1-(p-Chlorophenyl)-3-(2,6-difluorobenzoyl)urea | Astonex | Difluron | Dimilin | Dimilin G1 | Dimilin G4 | Dimilin ODC-45 | Dimilin WP-25 | Dioflubenzuron | Duphacid | Larvakil | Micromite | N-(((4-Chlorophenyl)amino)carbonyl)-2,6-difluorobenzamide | N-(4-Chlorophenyl)-N'-(2,6-difluorobenzoyl)urea | N-(4-Chlorophenylcarbamoyl)-2,6-difluorobenzamide | N-[(4-Chlorophenyl)carbamoyl]-2,6-difluorobenzamide | N-[[(4-Chlorophenyl)amino]carbonyl]-2,6-difluorobenzamide | 9CI | N-[[(4-Chlorophenyl)amno]carbonyl]-2,6-difluorobenzamide | Philips-duphar PH 60-40 | Thompson Hayward 6040 | Thompson-Hayward 6040 | Thompson-hayward TH6040
  • DESCRIPTION: Insecticide, interfering with chitin deposition by oral absorption. Diflubenzuron is used on soya beans, citrus, tea, vegetables and mushrooms. Also used as an insecticide in feed for poultry and pigs and as a controlled release bolus in cattle Diflubenzuron belongs to the family of N-Phenylureas. These are compounds containing a N-phenylurea moiety, which is structurally characterized by a phenyl group linked to one nitrogen atom of an urea group.
  • COMMENTS: Residues of this pesticide are tested for on Australian Foods | Pesticide approved in Australia
  • toxin chemical structure pubchem
  • FORMULA: C14H9ClF2N2O2
  • DATA SOURCES: DATA SOURCES: T3DB | PubChem | Consolidated Pesticide Information Dataset (CPI) from the USA EPA | Compendium of Pesticide Common Names | APVMA | DPR | EU Pesticides | Rural Industries Research and Development Corporation; Honeybee pesticide poisoning: a risk management tool for Australian farmers and beekeepers 2012 | Beekeeping -Department of Entomology - PROTECTING HONEY BEES FROM PESTICIDES, Christian H. Krupke et al.; www.extension.purdue.edu
  • LAST UPDATE: 26/04/2018

  Health Associations

Mostly focused on Health Implications of Long Term Exposure to this substance

  • SYMPTOMS:
  • POSSIBLE HEALTH CONSEQUENCES: One of the metabolites of diflubenzuron, PCA, has severe health effects. It is associated with cancer of the spleen and liver and osteosarcomas in male rats. Another metabolite of diflubenzuron also has carcinogenic potential and the same carcinogenic potency as PCA. |
  • ACTION OF TOXIN: One of the metabolites of diflubenzuron, PCA, is a proximate carcinogen. It is conjugated to form the carcinogen that can ionize and reat with DNA to form adducts which result in splenic tumor formation. |
  • TOXIN SITES OF ACTION IN CELL: "Membrane"
  • Additional Exposure Routes:

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  Exposure Routes

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