Medroxyprogesterone Acetate
Identification Number: CASRN | 71-58-9

  Substance Attributes

• Known Human Carcinogen

  This is a serious nasty substance. Exposure to this substance leads to cancer in Humans. Exercise extreme caution with this substance, explore your exposure routes and very seriously consider complete avoidance. See further details under Toxins.

• Birth/Developmental

  Known to effect development of fetus.

• Metabolic Interference or Disruption

  Interferes with human metabolism. This can be a very serious thing. Some of these interference mechanics are well established. However, often long term effects and health consequences remain largely unknown. Additionally an emerging area of concern and one that is not currently studied, is the combined synergistic effects these metabolically disrupting chemicals have on human health.

  
  

  Metabolic interference happens when the substance produces highly reactive and often damaging intermediates during detoxification or when the substance binds to specific enzymes, important structural groups on molecules, receptors and membranes or targets DNA or mimics key nutrients.

• Exposure Produces Health Symptoms

  Symptoms maybe short term or long term depending on the exposure duration and intensity and effects areas like Cardiovascular, Gastrointestinal, Cognition, Fatigue. A substance with this attribute may cause an allergic skin reaction, serious eye irritation, allergy or asthma symptoms or breathing difficulties if inhaled.

• Has known Side Effects

  This is often the result of long or short term medication use. The same medication can have a range of side effects ranging from none at all to totally debilitating symptoms within different individuals. Reasons for this include individual genetics, individual detoxification capacity, nutrition status, duration of use and total number of medications being taken.

  
  

  It becomes very difficult to establish clear causes of symptoms when multiple medications are being taken at once.

  
  

  See SIDE EFFECTS LINKOUT at end of this profile.

These attributes are ONLY based on peer-reviewed evidence. See link to Data Sources below. Everyone benefits from knowing this stuff. Please Share.

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• CATEGORIES: Medication or Drug | Synthetic Toxin | PESTICIDE active ingredient | Pesticide or Plant Growth Regulator Approved in Australia | Medication Approved in USA
• SUBSTANCE LINEAGE: Organic Compounds | Lipids and Lipid-Like Molecules | Steroids and Steroid Derivatives | Pregnane Steroids | Gluco/Mineralocorticoids, Progestogins and Derivatives
• SYNONYMS: (6alpha)-17-(Acetyloxy)-6-methylpreg-4-ene-3,20-dione | 17-Acetoxy-6alpha-methylprogesterone | 17-Acetoxy-6α-methylprogesterone | 17alpha-Hydroxy-6alpha-methylprogesterone acetate | 17α-hydroxy-6α-methylprogesterone acetate | 6-alpha-Methyl-17-alpha-acetoxyprogesterone | 6-alpha-Methyl-17-alpha-hydroxyprogesterone acetate | 6alpha-Methyl-17-acetoxy progesterone | 6alpha-Methyl-17alpha-hydroxyprogesterone acetate | 6alpha-Methyl-4-pregnene-3,20-dion-17alpha-ol acetate | 6α-Methyl-17-acetoxy progesterone | 6α-Methyl-17α-hydroxyprogesterone acetate | Depo-provera | Depo-subq provera 104 | Makena | Medroxyacetate progesterone | Medroxyprogesterone 17-acetate | Medroxyprogesterone acetate | Medroxyprogesterone acetic acid | Methylacetoxyprogesterone | Metigestrona | MPA | Provera
• DESCRIPTION: Medroxyprogesterone acetate (INN, USAN, BAN), also known as 17‘±-hydroxy-6‘±-methylprogesterone acetate, and commonly abbreviated as MPA, is a steroidal progestin, a synthetic variant of the human hormone progesterone. It is used as a contraceptive, in hormone replacement therapy and for the treatment of endometriosis as well as several other indications. MPA is a more potent derivative of its parent compound medroxyprogesterone (MP). While medroxyprogesterone is sometimes used as a synonym for medroxyprogesterone acetate, what is normally being administered is MPA and not MP.
• COMMENTS: Residues of this pesticide are NOT tested for on Australian Foods even though the Pesticide is approved in Australia. This is partly so because this pesticide is not usually used around food agriculture. | Pesticide approved in Australia
• 
• FORMULA: C24H34O4
• DATA SOURCES: DATA SOURCES: T3DB | PubChem | IARC | OEHHA | APVMA | Drugbank | USA FDA APPROVED DRUG PRODUCTS
• LAST UPDATE: 28/04/2018

  Health Associations

Mostly focused on Health Implications of Long Term Exposure to this substance

• SYMPTOMS: Side effects include loss of bone mineral density, BMD changes in adult women, bleeding irregularities, cancer risks, and thromboembolic disorders.
• POSSIBLE HEALTH CONSEQUENCES: | Hepatic. Route of Elimination: Following oral dosing, MPA is extensively metabolized in the liver via hydroxylation, with subsequent conjugation and elimination in the urine. Most MPA metabolites are excreted in the urine as glucuronide conjugates with only minor amounts excreted as sulfates. Half Life: 50 days
• ACTION OF TOXIN: Progestins diffuse freely into target cells in the female reproductive tract, mammary gland, hypothalamus, and the pituitary and bind to the progesterone receptor. Once bound to the receptor, progestins slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH surge. |
• TOXIN SITES OF ACTION IN CELL: "Membrane"
• Additional Exposure Routes: Used as a contraceptive and to treat secondary amenorrhea, abnormal uterine bleeding, pain associated with endometriosis, endometrial and renal cell carcinomas, paraphilia in males, GnRH-dependent forms of precocious puberty, as well as to prevent endometrial changes associated with estrogens.
SEE MEDICATION SIDE EFFECTS

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