Toxno Substance Profile
Evidence-based data. We have more than 25,000 profiles on Toxno.
Use Search below to seek out more. Or browse the Exposure Routes; alternatively see our Lists that have more substances than notes in a Liszt virtuoso piano piece.
Substance Name

Identification Number: CASRN | 51707-55-2

  Substance Attributes

  • Metabolic Interference or Disruption

    Interferes with human metabolism. This can be a very serious thing. Some of these interference mechanics are well established. However, often long term effects and health consequences remain largely unknown. Additionally an emerging area of concern and one that is not currently studied, is the combined synergistic effects these metabolically disrupting chemicals have on human health.

    Metabolic interference happens when the substance produces highly reactive and often damaging intermediates during detoxification or when the substance binds to specific enzymes, important structural groups on molecules, receptors and membranes or targets DNA or mimics key nutrients.

  • Exposure Produces Health Symptoms

    Symptoms maybe short term or long term depending on the exposure duration and intensity and effects areas like Cardiovascular, Gastrointestinal, Cognition, Fatigue. A substance with this attribute may cause an allergic skin reaction, serious eye irritation, allergy or asthma symptoms or breathing difficulties if inhaled.

These attributes are ONLY based on peer-reviewed evidence. See link to Data Sources below. Everyone benefits from knowing this stuff. Please Share.

  • CATEGORIES: Pesticide | Synthetic Toxin | PESTICIDE active ingredient | organic | plant growth regulator | herbicide | Pesticide or Plant Growth Regulator Approved in Australia | Pesticide approved in USA (California)
  • SUBSTANCE LINEAGE: Organic Compounds | Benzenoids | Benzene and Substituted Derivatives | | Benzene and Substituted Derivatives
  • SYNONYMS: (N-1,2,3-Thiadiazolyl-5)-N'-phenylurea | (phenylamino)-N-(1,2,3-thiadiazol-5-yl)carboxamide | N-phenyl-N'-1,2,3-thiadiazol-5-ylurea | Thidiazuron | 1-Phenyl-3-(1,2,3-thiadiazol-5-yl)urea
  • DESCRIPTION: Thidiazuron is an herbicide and defoliant plant growth regulator used particularly in cotton crops. It is absorbed by leaves.
  • COMMENTS: Residues of this pesticide are tested for on Australian Foods | Pesticide approved in Australia
  • toxin chemical structure pubchem
  • DATA SOURCES: DATA SOURCES: T3DB | PubChem | Consolidated Pesticide Information Dataset (CPI) from the USA EPA | Compendium of Pesticide Common Names | APVMA | DPR
  • LAST UPDATE: 28/04/2018

  Health Associations

Mostly focused on Health Implications of Long Term Exposure to this substance

  • SYMPTOMS: Minor skin rash, nausea, and weakness (L2080).
  • POSSIBLE HEALTH CONSEQUENCES: Relatively few incidents of illness have been reported due to thidiazuron. Since 1992, OPP IDS has only reported 5 incidents as a result of thidiazuron exposure, which all show similar symptoms such as skin rash, nausea, and weakness. However, no medical treatment was required. (L2080) |
  • ACTION OF TOXIN: The US EPA has found no information indicating thidiazuron shares a common mechanism of toxicity with other substances. (L2080) |
  • TOXIN SITES OF ACTION IN CELL: "Cytoplasm", "Extracellular", "Tubulin"
  • Additional Exposure Routes: Thidiazuron has been registered for use as a pre-harvest cotton defoliant or growth regulator. It removes green leaves and immature fruiting structures, which contribute to cotton staining. (L2080)

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  Exposure Routes

These are the Exposure Routes we have so far for this substance. There are almost certainly more. We update this section regularly. The number of chemicals with 2 or more nastiness attributes in an exposure route is shown in orange. They grey badge shows the total amount of chemicals within the exposure route.

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