Toxno Substance Profile
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Substance Name

Cholic-acid
Identification Number: CASRN | 81-25-4

  Substance Attributes


  • Metabolic Interference or Disruption

    Interferes with human metabolism. This can be a very serious thing. Some of these interference mechanics are well established. However, often long term effects and health consequences remain largely unknown. Additionally an emerging area of concern and one that is not currently studied, is the combined synergistic effects these metabolically disrupting chemicals have on human health.


    Metabolic interference happens when the substance produces highly reactive and often damaging intermediates during detoxification or when the substance binds to specific enzymes, important structural groups on molecules, receptors and membranes or targets DNA or mimics key nutrients.

  • Has known Side Effects

    This is often the result of long or short term medication use. The same medication can have a range of side effects ranging from none at all to totally debilitating symptoms within different individuals. Reasons for this include individual genetics, individual detoxification capacity, nutrition status, duration of use and total number of medications being taken.


    It becomes very difficult to establish clear causes of symptoms when multiple medications are being taken at once.


    See SIDE EFFECTS LINKOUT at end of this profile.

These attributes are ONLY based on peer-reviewed evidence. See link to Data Sources below. Everyone benefits from knowing this stuff. Please Share.



  • CATEGORIES: Animal Toxin | Food Toxin | Natural Toxin | EAFUS (Everything Added to Food in the United States) | Medication or Drug | Medication Approved by the European Medicines Agency
  • SUBSTANCE LINEAGE: Organic Compounds | Lipids and Lipid-Like Molecules | Steroids and Steroid Derivatives | Bile Acids, Alcohols and Derivatives | Trihydroxy Bile Acids, Alcohols and Derivatives
  • SYNONYMS: 17b-[1-Methyl-3-carboxypropyl]etiocholane-3a,7a,12a-triol | 3a,7a,12a-Trihydroxy-5b-cholan-24-oate | 3a,7a,12a-Trihydroxy-5b-cholan-24-oic acid | 3a,7a,12a-Trihydroxy-5b-cholanate | 3a,7a,12a-Trihydroxy-5b-cholanic acid | 3a,7a,12a-Trihydroxy-5b-cholanoate | 3a,7a,12a-Trihydroxy-5b-cholanoic acid | 3a,7a,12a-Trihydroxy-b-cholanate | 3a,7a,12a-Trihydroxy-b-cholanic acid | 3a,7a,12a-Trihydroxy-beta-cholanate | 3a,7a,12a-Trihydroxy-beta-cholanic acid | 3a,7a,12a-Trihydroxycholanate | 3a,7a,12a-Trihydroxycholanic acid | 5b-Cholanic acid-3a,7a,12a-triol | 5b-Cholate | 5b-Cholic acid | Cholalate | Cholalic acid | Cholalin | Cholate | Colalin
  • DESCRIPTION: Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. Bile acids are steroid acids found predominantly in bile of mammals. The distinction between different bile acids is minute, depends only on presence or absence of hydroxyl groups on positions 3, 7, and 12. Bile acids are physiological detergents that facilitate excretion, absorption, and transport of fats and sterols in the intestine and liver. Bile acids are also steroidal amphipathic molecules derived from the catabolism of cholesterol. They modulate bile flow and lipid secretion, are essential for the absorption of dietary fats and vitamins, and have been implicated in the regulation of all the key enzymes involved in cholesterol homeostasis. Bile acids recirculate through the liver, bile ducts, small intestine and portal vein to form an enterohepatic circuit. They exist as anions at physiological pH and, consequently, require a carrier for transport across the membranes of the enterohepatic tissues. The unique detergent properties of bile acids are essential for the digestion and intestinal absorption of hydrophobic nutrients. Bile acids have potent toxic properties (e.g., membrane disruption) and there are a plethora of mechanisms to limit their accumulation in blood and tissues. (A3407, A3408, A3409, A3410). Orphacol is indicated for the treatment of inborn errors in primary bile-acid synthesis due to 3-hydroxy-5-C27-steroid oxidoreductase deficiency or 4-3-oxosteroid-5-reductase deficiency in infants, children and adolescents agedone month to 18 years and adults.
  • COMMENTS:
  • toxin chemical structure pubchem
  • FORMULA: C24H40O5
  • DATA SOURCES: DATA SOURCES: T3DB | PubChem | EAFUS | Drugbank | European Medicines Agency
  • LAST UPDATE: 26/04/2018

  Health Associations

Mostly focused on Health Implications of Long Term Exposure to this substance

  • SYMPTOMS:
  • POSSIBLE HEALTH CONSEQUENCES: Chronically high levels of cholic acid are associated with Familial Hypercholanemia. |
  • ACTION OF TOXIN:
  • TOXIN SITES OF ACTION IN CELL: "Extracellular", "Membrane"
  • Additional Exposure Routes: This is an endogenously produced metabolite found in the human body. It is used in metabolic reactions, catabolic reactions or waste generation.
  • SEE MEDICATION SIDE EFFECTS

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  Exposure Routes

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