Toxno Substance Profile
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Substance Name

Perfluorooctanoic acid
Identification Number: CASRN | 335-67-1

  Substance Attributes


  • Known Human Carcinogen

    This is a serious nasty substance. Exposure to this substance leads to cancer in Humans. Exercise extreme caution with this substance, explore your exposure routes and very seriously consider complete avoidance. See further details under Toxins.

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  • CATEGORIES: Industrial/Workplace Toxin | Synthetic Toxin
  • SUBSTANCE LINEAGE: Organic Compounds | Organohalogen Compounds | Alkyl halides | Alkyl fluorides | Medium-Chain Fatty Acids
  • SYNONYMS: 2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-Pentadecafluorooctanoic acid | Pentadecafluoro-1-octanoic acid | Pentadecafluoro-N-octanoic acid | Perfluoro-N-octanoic acid | Perfluorocaprylic acid | Perfluoroheptanecarboxylic acid | Perfluorooctanoate | PFOA
  • DESCRIPTION: Perfluorooctanoic acid (PFOA), also known as C8 and perfluorooctanoate, is a synthetic, stable perfluorinated carboxylic acid and fluorosurfactant. One industrial application is as a surfactant in the emulsion polymerization of fluoropolymers. It has been used in the manufacture of such prominent consumer goods as Teflon and Gore-Tex. PFOA has been manufactured since the 1940s in industrial quantities. It is also formed by the degradation of precursors such as some fluorotelomers. PFOA persists indefinitely in the environment. It is a toxicant and carcinogen in animals. PFOA has been detected in the blood of more than 98% of the general US population in the low and sub-parts per billion range, and levels are higher in chemical plant employees and surrounding subpopulations. Exposure has been associated with increased cholesterol and uric acid levels, and recently higher serum levels of PFOA were found to be associated with increased risk of chronic kidney disease in the general United States population, consistent with earlier animal studies. This association was independent of confounders such as age, sex, race/ethnicity, body mass index, diabetes, hypertension, and serum cholesterol level. .
  • COMMENTS:
  • toxin chemical structure pubchem
  • FORMULA: C8HF15O2
  • DATA SOURCES: DATA SOURCES: T3DB | PubChem | IARC
  • LAST UPDATE: 28/04/2018

  Health Associations

Mostly focused on Health Implications of Long Term Exposure to this substance

  • SYMPTOMS:
  • POSSIBLE HEALTH CONSEQUENCES:
  • ACTION OF TOXIN:
  • TOXIN SITES OF ACTION IN CELL: "Membrane"
  • Additional Exposure Routes: It has been used in the manufacture of such prominent consumer goods as Teflon and Gore-Tex. PFOA has been detected in the blood of more than 98% of the general US population in the low and sub-parts per billion range, and levels are higher in chemical plant employees and surrounding subpopulations. Exposure has been associated with increased cholesterol and uric acid levels, and recently higher serum levels of PFOA were found to be associated with increased risk of chronic kidney disease in the general United States population, consistent with earlier animal studies. This association was independent of confounders such as age, sex, race/ethnicity, body mass index, diabetes, hypertension, and serum cholesterol level.

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  Exposure Routes

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