Toxno Substance Profile
Evidence-based data. We have more than 25,000 profiles on Toxno.
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Substance Name

Ethyl acrylate
Identification Number: CASRN | 140-88-5

  Substance Attributes

  • Known Human Carcinogen

    This is a serious nasty substance. Exposure to this substance leads to cancer in Humans. Exercise extreme caution with this substance, explore your exposure routes and very seriously consider complete avoidance. See further details under Toxins.

  • Carcinogenic Properties

    Accumulating evidence points to cancer potential. Exercise caution with this substance, explore your exposure routes and consider complete avoidance. See further details under Toxins.

  • Metabolic Interference or Disruption

    Interferes with human metabolism. This can be a very serious thing. Some of these interference mechanics are well established. However, often long term effects and health consequences remain largely unknown. Additionally an emerging area of concern and one that is not currently studied, is the combined synergistic effects these metabolically disrupting chemicals have on human health.

    Metabolic interference happens when the substance produces highly reactive and often damaging intermediates during detoxification or when the substance binds to specific enzymes, important structural groups on molecules, receptors and membranes or targets DNA or mimics key nutrients.

  • Exposure Produces Health Symptoms

    Symptoms maybe short term or long term depending on the exposure duration and intensity and effects areas like Cardiovascular, Gastrointestinal, Cognition, Fatigue. A substance with this attribute may cause an allergic skin reaction, serious eye irritation, allergy or asthma symptoms or breathing difficulties if inhaled.

These attributes are ONLY based on peer-reviewed evidence. See link to Data Sources below. Everyone benefits from knowing this stuff. Please Share.

  • CATEGORIES: Household Toxin | Industrial/Workplace Toxin | Pollutant | Airborne Pollutant | Plant Toxin | Food Toxin | Natural Toxin | Food Flavoring | EAFUS (Everything Added to Food in the United States) | A Hazardous Substance that may be found in the Australian Workplace
  • SUBSTANCE LINEAGE: Organic Compounds | Organic Acids and Derivatives | Carboxylic Acids and Derivatives | Carboxylic Acid Derivatives | Enoate Esters
  • SYNONYMS: 2-Propenoic acid ethyl ester | 2-Propenoic acid | ethyl ester | 2-Propenoic acid | ethyl ester | homopolymer | Acrylic acid ethyl ester | Acrylic acid | ethyl ester | Acrylic acid | ethyl ester (inhibited) | Aethylacrylat | Akrylanem etylu | Carboset 511 | CH2=CHCOOC2H5 | Ethoxycarbonylethylene | Ethyl 2-propenoate | Ethyl 2-propenoate | homopolymer | Ethyl acrylate (inhibited) | Ethyl acrylate homopolymer | Ethyl acrylate polymer | Ethyl acrylate | inhibited | Ethyl acrylic acid | Ethyl ester of 2-propenoic acid | Ethyl propenoate | Ethyl propenoate | inhibited | Ethylacrylaat | Ethylakrylat | Ethylester kyseliny akrylove | Etil acrilato | Etilacrilatului | Etilacrilatului(roumanian) | FEMA 2418 | Poly(acrylic acid | ethyl ester) | Poly(ethyl acrylate) | Polyethylacrylate | Propenoic acid,ethyl ester (ethylacrylate)
  • DESCRIPTION: Ethyl acrylate is found in pineapple. Ethyl acrylate is a flavouring ingredient Although there are some reports claiming that ethyl acrylate is a carcinogen, major respected bodies regard the evidence of human carcinogenicity as weak and/or inconsistent. The International Agency for Research on Cancer stated, Overall evaluation, Ethyl acrylate is possibly carcinogenic to humans (Group 2B). The United States Environmental Protection Agency (EPA) states, Human studies on occupational exposure to ethyl acrylate… have suggested a relationship between exposure to the chemical(s) and colorectal cancer, but the evidence is conflicting and inconclusive. In a study by the National Toxicology Program (NTP), increased incidences of squamous cell papillomas and carcinomas of the forestomach were observed in rats and mice exposed via gavage (experimentally placing the chemical in the stomach). However, the NTP recently determined that these data were not relevant to human carcinogenicity and removed ethyl acrylate from its list of carcinogens. (Occupational exposure generally involves exposure that occurs regularly, over an extended period of time). Ethyl acrylate is an organic compound primarily used in the preparation of various polymers. It is a clear liquid with an acrid penetrating odor. The human nose is capable of detecting this odor at a thousand times lower concentration then is considered harmful if continuously exposed for some period of time.

    From Safe Work Australia and the Hazardous Substances Information System (HSIS) in Australia:

    Highly flammable liquid and vapour. Harmful if inhaled. Harmful in contact with skin. Harmful if swallowed. Causes serious eye irritation. May cause respiratory irritation. Causes skin irritation. May cause an allergic skin reaction | General Health Hazard | A Hazardous Substance that may be found in the Australian Workplace. Check with your employer or health and safety officer. Stay informed and become aware of the dangers that surround you. This chemical is included on the list of recognised hazardous chemicals from the Safe Work Australia - Hazardous Substances Information System (HSIS) that is based on the Globally Harmonised System of Classification and Labelling of Chemicals (GHS)

    Work Health and Safety (WHS) Regulations are the basis for hazardous chemicals regulations in Commonwealth, State and Territory jurisdictions in Australia. Under the model WHS Regulations, manufacturers and importers of substances, mixtures and articles supplied for use in workplaces are required to determine whether they are hazardous to health and safety before supply. The model WHS Regulations mandate that the hazards of a chemical as determined by the Globally Harmonised System of Classification and Labelling of Chemicals (GHS) must be included in safety data sheets and on labels. There are transitional arrangements in place for moving to the GHS-based system.

    The GHS Hazardous Chemical Information List contains chemicals classified by an authoritative source (such as the European Commission or NICNAS) in accordance with the Globally Harmonized System of Classification and Labelling of Chemicals (the GHS). This list contains the vast majority of chemicals currently in HSIS. This list and its detail are regularly updated by Work Safe Australia. The model Work Health and Safety (WHS) Regulations require chemicals to be classified in accordance with the Globally Harmonised System of Classification and Labelling of Chemicals (GHS). However transitional arrangements allow use of classification information in HSIS derived from the Approved Criteria until the 31 December 2016.
  • toxin chemical structure pubchem
  • DATA SOURCES: DATA SOURCES: ARTICLE 4 | CPDB | T3DB | PubChem | IARC | OEHHA | Flavornet | EAFUS | Safe Work Australia - Hazardous Substances Information System (HSIS)
  • LAST UPDATE: 28/04/2018

  Health Associations

Mostly focused on Health Implications of Long Term Exposure to this substance

  • SYMPTOMS: Lethargy and convulsions may occur if vapors are inhaled in high concentrations. Ethyl acrylate is irritating to the mucous membranes of the gastrointestinal tract and respiratory system. Prolonged exposure may produce drowsiness, headache and nausea . Iching of the skin and the face can also occur (T63, T21).
  • POSSIBLE HEALTH CONSEQUENCES: Thickened forestomach mucosa, forestomach inflammation and lesions, and abdominal adhesions; swelling of renal tubules and the liver, minor lesions on the liver and lung, and increased kidney weight may result from poisoning (L1242). | Ethyl acrylate is hydrolized to acrylic acid in liver, kidney, and lung homogenates. It is suggested to bind to glutathione spontaneaoulsy and after catalysis by liver glutathione-S-transferase. The major metabolites of ethyl acrylate are mercapturic acids od ethyl acrylate and acrylic acid. Three metabolites were identified in a study: 3-hydroxypropionic acid and two mercapturic acids. N-Acetyl-S-(2-carboxyethyl)cysteine arises by glutathione conjugation of acrylic acid, while N-acetyl-S-(2-carboxyethyl)cysteine ethyl ester derives from the conjugation of intact ethyl acrylate.(A347, A635, A664, ).
  • ACTION OF TOXIN: Ethyl acrylate causes gastric lesions depending upon upon the rate of chemical delivery to stomach tissue as a result of interaction of the parent molecule or metabolites (other than hydrolysis products), with subcellular sites in stomach tissue (A2451). |
  • TOXIN SITES OF ACTION IN CELL: "Cytoplasm", "Extracellular"
  • Additional Exposure Routes: Ethyl acrylate is used in the production of polymers including resins, plastics, rubber, and denture material (L1233).

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  Exposure Routes

These are the Exposure Routes we have so far for this substance. There are almost certainly more. We update this section regularly. The number of chemicals with 2 or more nastiness attributes in an exposure route is shown in orange. They grey badge shows the total amount of chemicals within the exposure route.

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