Toxno Substance Profile
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Substance Name

2-Propenyl 3-methylbutanoate
Identification Number: CASRN | 2835-39-4

  Substance Attributes


  • Carcinogenic Properties

    Accumulating evidence points to cancer potential. Exercise caution with this substance, explore your exposure routes and consider complete avoidance. See further details under Toxins.

  • Metabolic Interference or Disruption

    Interferes with human metabolism. This can be a very serious thing. Some of these interference mechanics are well established. However, often long term effects and health consequences remain largely unknown. Additionally an emerging area of concern and one that is not currently studied, is the combined synergistic effects these metabolically disrupting chemicals have on human health.


    Metabolic interference happens when the substance produces highly reactive and often damaging intermediates during detoxification or when the substance binds to specific enzymes, important structural groups on molecules, receptors and membranes or targets DNA or mimics key nutrients.

  • Exposure Produces Health Symptoms

    Symptoms maybe short term or long term depending on the exposure duration and intensity and effects areas like Cardiovascular, Gastrointestinal, Cognition, Fatigue. A substance with this attribute may cause an allergic skin reaction, serious eye irritation, allergy or asthma symptoms or breathing difficulties if inhaled.

These attributes are ONLY based on peer-reviewed evidence. See link to Data Sources below. Everyone benefits from knowing this stuff. Please Share.



  • CATEGORIES: Household Toxin | Food Toxin | Synthetic Toxin | EAFUS (Everything Added to Food in the United States)
  • SUBSTANCE LINEAGE: Organic Compounds | Lipids and Lipid-Like Molecules | Fatty Acyls | Fatty Acid Esters | Fatty Acid Esters
  • SYNONYMS: 2-Propenyl 3-methylbutanoic acid | 2-Propenyl isopentanoate | 2-Propenyl isovalerate | 3-Methylbutanoic acid | 2-propenyl ester | 3-Methylbutyric acid | allyl ester | Allyl 3-methylbutanoate | Allyl 3-methylbutyrate | Allyl isopentanoate | Allyl isovalerate | Allyl isovalerianate | Allylisovalerate | Butanoic acid | 3-methyl- | 2-propen-1-yl ester | Butanoic acid | 3-methyl- | 2-propenyl ester | Butyric acid | 3-methyl- | allyl ester | Isovaleric acid | allyl ester
  • DESCRIPTION: 2-Propenyl 3-methylbutanoate is a flavouring ingredient.
  • COMMENTS:
  • toxin chemical structure pubchem
  • FORMULA: C8H14O2
  • DATA SOURCES: DATA SOURCES: T3DB | PubChem | IARC | EAFUS
  • LAST UPDATE: 28/04/2018

  Health Associations

Mostly focused on Health Implications of Long Term Exposure to this substance

  • SYMPTOMS: Irritating to eyes, respiratory system, and skin. Headache, rhinorrhea, cough, shortness of breath, chest pain (L1275).
  • POSSIBLE HEALTH CONSEQUENCES: Harmful in contact with skin and if swallowed. Exposure via inhalation may result in bronchospasm and rarely, upper airway swelling or acute lung injury (T36, L1275). | Allyl isovalerate is metabolized to isovaleric acid, which can conjugate with glycine, and allyl alcohol, which could then be further metabolized via two pathways to form either acrolein or glycidol, from which a variety of metabolites could result (L1276).
  • ACTION OF TOXIN: Allyl isovalerate has low irritancy potential. It is deduced that one of its metabolites, isovaleric acid, is toxic, based upon the effects of an inborn error of leucine metabolism caused by isovaleryl-coenzyme A dehydrogenase deficiency (L1276). |
  • TOXIN SITES OF ACTION IN CELL: "Cytoplasm", "Extracellular", "Membrane"
  • Additional Exposure Routes: Allyl isovalerate has been used since the 1950s as a raw material for fragrances in cosmetics, lotions and perfumes and in certain food products, although it is not known whether it is currently used in this way (L1276).

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  Exposure Routes

These are the Exposure Routes we have so far for this substance. There are almost certainly more. We update this section regularly. The number of chemicals with 2 or more nastiness attributes in an exposure route is shown in orange. They grey badge shows the total amount of chemicals within the exposure route.


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