Toxno Substance Profile
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Substance Name

Cinobufagin
Identification Number: CASRN | 470-37-1

  Substance Attributes


  • Metabolic Interference or Disruption

    Interferes with human metabolism. This can be a very serious thing. Some of these interference mechanics are well established. However, often long term effects and health consequences remain largely unknown. Additionally an emerging area of concern and one that is not currently studied, is the combined synergistic effects these metabolically disrupting chemicals have on human health.


    Metabolic interference happens when the substance produces highly reactive and often damaging intermediates during detoxification or when the substance binds to specific enzymes, important structural groups on molecules, receptors and membranes or targets DNA or mimics key nutrients.

  • Exposure Produces Health Symptoms

    Symptoms maybe short term or long term depending on the exposure duration and intensity and effects areas like Cardiovascular, Gastrointestinal, Cognition, Fatigue. A substance with this attribute may cause an allergic skin reaction, serious eye irritation, allergy or asthma symptoms or breathing difficulties if inhaled.

These attributes are ONLY based on peer-reviewed evidence. See link to Data Sources below. Everyone benefits from knowing this stuff. Please Share.



  • CATEGORIES: Animal Toxin | Natural Toxin
  • SUBSTANCE LINEAGE: Organic Compounds | Lipids and Lipid-Like Molecules | Steroids and Steroid Derivatives | Steroid Esters | Hydroxysteroids
  • SYNONYMS: Cino-bufagin | Cinobufagine
  • DESCRIPTION: Cinobufagin is a cardiotoxic bufanolide steroid secreted by the Asiatic toad (Bufo gargarizans). (L1083)
  • COMMENTS:
  • toxin chemical structure pubchem
  • FORMULA: C26H34O6
  • DATA SOURCES: DATA SOURCES: T3DB | PubChem
  • LAST UPDATE: 28/04/2018

  Health Associations

Mostly focused on Health Implications of Long Term Exposure to this substance

  • SYMPTOMS: Symptoms include nausea, vomiting, anorexia, diarrhoea, abdominal pain, wild hallucinations, delirium, and severe headache. Depending on the severity the victim may later suffer irregular and slow pulse, tremors, various cerebral disturbances, especially of a visual nature, convulsions, and deadly disturbances of the heart such as heart block, brachycardia, or tachycardia. (L1083, L1084)
  • POSSIBLE HEALTH CONSEQUENCES: Cinobufagin is cardiotoxic. (L1083) |
  • ACTION OF TOXIN: Cinobufagin blocks the sodium/potassium pump in heart tissue. (L1083, L1084) |
  • TOXIN SITES OF ACTION IN CELL: "Membrane"
  • Additional Exposure Routes: Cinobufagin is a cardiotoxic bufanolide steroid secreted by the Asiatic toad (Bufo gargarizans). (L1083)

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  Exposure Routes

These are the Exposure Routes we have so far for this substance. There are almost certainly more. We update this section regularly. The number of chemicals with 2 or more nastiness attributes in an exposure route is shown in orange. They grey badge shows the total amount of chemicals within the exposure route.


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