Toxno Substance Profile
Evidence-based data. We have more than 25,000 profiles on Toxno.
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Substance Name

Diphenylamine
Identification Number: CASRN | 122-39-4

  Substance Attributes


  • Exposure Produces Health Symptoms

    Symptoms maybe short term or long term depending on the exposure duration and intensity and effects areas like Cardiovascular, Gastrointestinal, Cognition, Fatigue. A substance with this attribute may cause an allergic skin reaction, serious eye irritation, allergy or asthma symptoms or breathing difficulties if inhaled.

  • Serious Acute Effects

    This is a serious nasty substance. Effects are Acute (seen immediately). Substances in this category may be FATAL or acutely toxic if inhaled, skin contact or swallowed. See further details.

  • Toxic to specific organs

    Can damage liver, kidney, lungs, heart or gut. Ironically liver, kidneys and gut are the main detoxifications systems.

  • Toxic to Wildlife

    May kill plants, fish, birds or other animals and insects or may be very toxic to aquatic life with long lasting effects. This then effects delicate environmental ecology and food supply in ways we don't fully understand yet.

These attributes are ONLY based on peer-reviewed evidence. See link to Data Sources below. Everyone benefits from knowing this stuff. Please Share.



  • CATEGORIES: Chemicals detected in flowback and produced water - collectively referred to as - hydraulic fracturing wastewater | Pesticide | Household Toxin | Plant Toxin | Food Toxin | Natural Toxin | Indirect Additives Used in Food Contact Substances | PESTICIDE active ingredient | organic | fungicide | Pesticide or Plant Growth Regulator Approved in Australia | Pesticide approved in USA (California) | A Hazardous Substance that may be found in the Australian Workplace
  • SUBSTANCE LINEAGE: Organic Compounds | Benzenoids | Benzene and Substituted Derivatives | | Benzene and Substituted Derivatives
  • SYNONYMS: (phenylamino)-Benzene | (phenylamino)benzene | 2-Biphenylyl-N-pyridyl-Acetamide | 2-Biphenylyl-N-pyridylacetamide | Anilino-Benzene | Anilinobenzene | Benzenamine | N-phenyl- | styrenated | Big dipper | C6H5-NH-C6H5 | Deccoscald 282 | DFA | Difenylamin | Diphenpyramide | Diphenyl-amine | Diphenylamine indicator | Diphenylamine | acs | Diphenylamine | reaction product with 2,2,4-trimethylpentene | N,N-Diphenylamine | N-Fenylanilin | N-Phenyl-Aniline | N-Phenyl-Benzenamine | N-Phenylaniline | N-Phenylbenzenamine | N-Phenylbenzenamine | 9CI | N-Phenylbenzenamine | styrenated | N-Phenylbenzeneamine | Naugalube 428L | No scald | No scald dpa 283 | No-scald | No-Scald DPA 283 | Phenylaniline | Poly(diphenylamine) | Pyridyl-biphenylyl-acetamide | Scaldip | Shield dpa | Styrenated diphenylamine | Styrene | reaction product with diphenylamine
  • DESCRIPTION: Has been used in CSG, Hydraulic Fracturing Operations (Fracking) as - Unknown | Diphenylamine is found in coriander. Diphenylamine is used for control of superficial scald in stored apples Diphenylamine is the organic compound with the formula (C6H5)2NH. It is a colourless solid, but samples are often yellow due to oxidized impurities. It is a weak base, with a KB of 10 14. With strong acids, it forms the water soluble salt. Diphenylamine belongs to the family of Aromatic Homomonocyclic Compounds. These are aromatic compounds containig only one ring, which is homocyclic.
  • COMMENTS: Residues of this pesticide are tested for on Australian Foods | Pesticide approved in Australia

    From Safe Work Australia and the Hazardous Substances Information System (HSIS) in Australia:

    Toxic if inhaled. Toxic in contact with skin. Toxic if swallowed. May cause damage to organs through prolonged or repeated exposure . Very toxic to aquatic life with long lasting effects | Chronic Health Hazard Environmental Hazard Acutely Toxic | A Hazardous Substance that may be found in the Australian Workplace. Check with your employer or health and safety officer. Stay informed and become aware of the dangers that surround you. This chemical is included on the list of recognised hazardous chemicals from the Safe Work Australia - Hazardous Substances Information System (HSIS) that is based on the Globally Harmonised System of Classification and Labelling of Chemicals (GHS)

    Work Health and Safety (WHS) Regulations are the basis for hazardous chemicals regulations in Commonwealth, State and Territory jurisdictions in Australia. Under the model WHS Regulations, manufacturers and importers of substances, mixtures and articles supplied for use in workplaces are required to determine whether they are hazardous to health and safety before supply. The model WHS Regulations mandate that the hazards of a chemical as determined by the Globally Harmonised System of Classification and Labelling of Chemicals (GHS) must be included in safety data sheets and on labels. There are transitional arrangements in place for moving to the GHS-based system.

    The GHS Hazardous Chemical Information List contains chemicals classified by an authoritative source (such as the European Commission or NICNAS) in accordance with the Globally Harmonized System of Classification and Labelling of Chemicals (the GHS). This list contains the vast majority of chemicals currently in HSIS. This list and its detail are regularly updated by Work Safe Australia. The model Work Health and Safety (WHS) Regulations require chemicals to be classified in accordance with the Globally Harmonised System of Classification and Labelling of Chemicals (GHS). However transitional arrangements allow use of classification information in HSIS derived from the Approved Criteria until the 31 December 2016.
  • toxin chemical structure pubchem
  • FORMULA: C12H11N
  • DATA SOURCES: DATA SOURCES: ARTICLE 4 | T3DB | PubChem | EPA in USA | FDA Indirect Food Additives | Consolidated Pesticide Information Dataset (CPI) from the USA EPA | Compendium of Pesticide Common Names | APVMA | DPR | Safe Work Australia - Hazardous Substances Information System (HSIS)
  • LAST UPDATE: 28/04/2018

  Health Associations

Mostly focused on Health Implications of Long Term Exposure to this substance

  • SYMPTOMS:
  • POSSIBLE HEALTH CONSEQUENCES:
  • ACTION OF TOXIN: Diphenylamine uncouples mitochondrial oxidative phosphorylation, resulting in a decrease in hepatocellular ATP content and consequently hepatocyte injury (A15350). Short-term and long-term exposure in animal models results in altered haematological parameters, splenic erythropoiesis, splenic congestion and haemosiderosis (L2078). |
  • TOXIN SITES OF ACTION IN CELL: "Membrane"
  • Additional Exposure Routes: This is a natural compound that is used as a pesticide.

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  Exposure Routes

These are the Exposure Routes we have so far for this substance. There are almost certainly more. We update this section regularly. The number of chemicals with 2 or more nastiness attributes in an exposure route is shown in orange. They grey badge shows the total amount of chemicals within the exposure route.


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