Metabolic Interference or Disruption
Interferes with human metabolism. This can be a very serious thing. Some of these interference mechanics are well established. However, often long term effects and health consequences remain largely unknown. Additionally an emerging area of concern and one that is not currently studied, is the combined synergistic effects these metabolically disrupting chemicals have on human health.
Metabolic interference happens when the substance produces highly reactive and often damaging intermediates during detoxification or when the substance binds to specific enzymes, important structural groups on molecules, receptors and membranes or targets DNA or mimics key nutrients.
Exposure Produces Health Symptoms
Symptoms maybe short term or long term depending on the exposure duration and intensity and effects areas like Cardiovascular, Gastrointestinal, Cognition, Fatigue. A substance with this attribute may cause an allergic skin reaction, serious eye irritation, allergy or asthma symptoms or breathing difficulties if inhaled.
These attributes are ONLY based on peer-reviewed evidence. See link to Data Sources below. Everyone benefits from knowing this stuff. Please Share.
- CATEGORIES: Chemicals detected in flowback and produced water - collectively referred to as - hydraulic fracturing wastewater | Pesticide | Household Toxin | Industrial/Workplace Toxin | Pollutant | Food Toxin | Synthetic Toxin | Indirect Additives Used in Food Contact Substances
- SUBSTANCE LINEAGE: Organic Compounds | Benzenoids | Benzene and Substituted Derivatives | Benzoic Acids and Derivatives | o-Phthalic Acid and Derivatives
- SYNONYMS: -benzenedicarboxylic acid diethyl ester | 1,2-Benzenedicarboxylic acid 1,2-diethyl ester | 1,2-Benzenedicarboxylic acid di-C4-13-alkyl esters | 1,2-Benzenedicarboxylic acid diethyl ester | 1,2-benzenedicarboxylic acid diethyl ester | 1,2-Diethyl phthalate | Anozol | Benzenedicarboxylic acid diethyl ester | Di-n-ethyl phthalate | Diethyl 1,2-benzenedicarboxylate | Diethyl benzene-1,2-dicarboxylate | Diethyl ester | Diethyl ester of 1,2-Benzenedicarboxylic acid | Diethyl o-phenylenediacetate | Diethyl o-phthalate | Diethyl phthalate (NF) | Diethyl phthalic acid | Diethyl-1,2-benzenedicarboxylate | Diethyl-o-phthalate | Diethylphthalate | Ethyl phthalate | Iethylphthalate | Kodaflex dep | Neantine | O-benzenedicarboxylic acid diethyl ester | O-bis(ethoxycarbonyl)benzene | Phthalic acid diethyl ester | Phthalol | Phthalsaeurediaethylester | Placidol e | Solvanol | Unimoll da
- DESCRIPTION: Has been used in CSG, Hydraulic Fracturing Operations (Fracking) as - Unknown | Diethyl phthalate is a phthalate ester. This synthetic substance is commonly used to make plastics more flexible. Products in which it is found include toothbrushes, automobile parts, tools, toys, and food packaging. Diethyl phthalate can be released fairly easily from these products, as it is not part of the chain of chemicals (polymers) that makes up the plastic. Diethyl phthalate is also used in cosmetics, insecticides, and aspirin. Phthalate esters can cause reproductive and developmental toxicity. (L1900, A2883)
- FORMULA: C12H14O4
- DATA SOURCES: DATA SOURCES: ARTICLE 4 | T3DB | PubChem | EPA in USA | FDA Indirect Food Additives
- LAST UPDATE: 28/04/2018
Mostly focused on Health Implications of Long Term Exposure to this substance
- SYMPTOMS: Diethyl phtalate may cause skin and eye irritation. (L1900)
- POSSIBLE HEALTH CONSEQUENCES: Phthalate esters are endocrine disruptors. Animal studies have shown that they disrupt reproductive development and can cause a number of malformations in affected young, such as reduced anogenital distance (AGD), cryptorchidism, hypospadias, and reduced fertility. The combination of effects associated with phthalates is called 'phthalate syndrome’. (A2883) | Diethyl phthalate is hydrolyzed to its monoester derivative by diethyl phthalate hydrolase. Once formed, the monoester derivative can be further hydrolyzed in vivo to phthalic acid or conjugated to glucuronide, both of which can then be excreted. The terminal or next-to-last carbon atom in the monoester can also be oxidized to an alcohol, which can be excreted as is or first oxidized to an aldehyde, ketone, or carboxylic acid. The monoester and oxidative metabolites are excreted in the urine and faeces. (L1900, A2884)
- ACTION OF TOXIN: Phthalate esters are endocrine disruptors. They decrease foetal testis testosterone production and reduce the expression of steroidogenic genes by decreasing mRNA expression. Some phthalates have also been shown to reduce the expression of insulin-like peptide 3 (insl3), an important hormone secreted by the Leydig cell necessary for development of the gubernacular ligament. Animal studies have shown that these effects disrupt reproductive development and can cause a number of malformations in affected young. (A2883) |
- TOXIN SITES OF ACTION IN CELL: "Membrane"
- Additional Exposure Routes: Diethyl phthalate is commonly used to make plastics more flexible. Products in which it is found include toothbrushes, automobile parts, tools, toys, and food packaging. Diethyl phthalate can be released fairly easily from these products, as it is not part of the chain of chemicals (polymers) that makes up the plastic. Diethyl phthalate is also used in cosmetics, insecticides, and aspirin. (L1900)
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