Toxno Substance Profile
Evidence-based data. We have more than 25,000 profiles on Toxno.
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Substance Name

Identification Number: CASRN | 51218-45-2

  Substance Attributes

  • Known Human Carcinogen

    This is a serious nasty substance. Exposure to this substance leads to cancer in Humans. Exercise extreme caution with this substance, explore your exposure routes and very seriously consider complete avoidance. See further details under Toxins.

  • Metabolic Interference or Disruption

    Interferes with human metabolism. This can be a very serious thing. Some of these interference mechanics are well established. However, often long term effects and health consequences remain largely unknown. Additionally an emerging area of concern and one that is not currently studied, is the combined synergistic effects these metabolically disrupting chemicals have on human health.

    Metabolic interference happens when the substance produces highly reactive and often damaging intermediates during detoxification or when the substance binds to specific enzymes, important structural groups on molecules, receptors and membranes or targets DNA or mimics key nutrients.

  • Exposure Produces Health Symptoms

    Symptoms maybe short term or long term depending on the exposure duration and intensity and effects areas like Cardiovascular, Gastrointestinal, Cognition, Fatigue. A substance with this attribute may cause an allergic skin reaction, serious eye irritation, allergy or asthma symptoms or breathing difficulties if inhaled.

These attributes are ONLY based on peer-reviewed evidence. See link to Data Sources below. Everyone benefits from knowing this stuff. Please Share.

  • CATEGORIES: Pesticide | Synthetic Toxin | PESTICIDE active ingredient | organic | herbicide | Pesticide or Plant Growth Regulator Approved in Australia | Pesticide approved in USA (California)
  • SUBSTANCE LINEAGE: Organic Compounds | Benzenoids | Benzene and Substituted Derivatives | Anilides | Anilides
  • SYNONYMS: Bicep | Bicep 6L | Caswell No. 188DD | Codal | DUAL | Dual 25G | Dual 720EC | Dual 8E | Dual 960 EC | Dual II | Dual magnum | Dual triple | Humextra | Metelilachlor | Metetilachlor | Metolachlor (pesticide/fertilizer mixture) | Metolachlor technical | Metolachlor | herbicide (C15-H22-N-O2-Cl) | Metolaclor | Ontrack 8E | Pace 6L | Pennant | Primagram | Primextra | Turbo | Yibingjiacaoan
  • DESCRIPTION: Widely used selective herbicides worldwide in corn, soybean and other crop cultures. Elevated concentrations of these herbicides and their degradation products have been detected in surface and groundwater. (A252) Metolachlor is an organic compound that is widely used as a herbicide. It is a derivative of aniline and is a member of the chloroacetanilide herbicides. It is highly effective toward grasses but its application is also controversial (L913).
  • COMMENTS: Residues of this pesticide are tested for on Australian Foods | Pesticide approved in Australia
  • toxin chemical structure pubchem
  • FORMULA: C15H22ClNO2
  • DATA SOURCES: DATA SOURCES: T3DB | PubChem | EPA_IRIS | Consolidated Pesticide Information Dataset (CPI) from the USA EPA | Compendium of Pesticide Common Names | APVMA | DPR
  • LAST UPDATE: 28/04/2018

  Health Associations

Mostly focused on Health Implications of Long Term Exposure to this substance

  • SYMPTOMS: Signs of human intoxication from metolachlor and/or its formulations (presumably following acute deliberate or accidental exposures) include abdominal cramps, anemia, ataxia, dark urine, methemoglobinemia, cyanosis, hypothermia, collapse, convulsions, diarrhea, GI irritation, jaundice, weakness, nausea, shock, sweating, vomiting, skin irritation, dermatitis, sensitization dermatitis, eye and mucous membrane irritation, and corneal opacity. (A571)
  • POSSIBLE HEALTH CONSEQUENCES: Health effects of metolachlor include CNS depression, dizziness, dyspnea, liver damage, nephritis, cardiovascular failure, and adverse reproductive effects. (A571) | Metolachlor is metabolized via dechlorination, o-methylation, N-dealkylation and side-chain oxidation. Glutathione transferases mediathe the conjugation of metolachlor with with glutathione. Urinary metabolites included 2-ethyl-6-methylhydroxyacetanilide and N-(2-ethyl-6-methyl- phenyl)-N-(hydroxyacetyl)-DL-alanine). Fecal metabolites included 2-chloro-N-(2-ethyl-6-methylphenyl)-N-(2-hydroxy-l-methylethyl) and N-(2-ethyl-6-methylphenyl)-N-(hydroxyacetyl)-DL-alamine). Metolachlor is also excreted in urine. (A571, A270)
  • ACTION OF TOXIN: Metolachlor acts by inhibition of elongases and of the geranylgeranyl pyrophosphate (GGPP) cyclases, which are part of the gibberellin pathway. It also binds to nAChRs in nervous systems and causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (T10, L913, A590) | Metolachlor acts by inhibition of elongases and of the geranylgeranyl pyrophosphate (GGPP) cyclases, which are part of the gibberellin pathway. It also binds to nAChRs in nervous systems. (T10, L913)
  • Additional Exposure Routes: Metolachlor is used for grass and broadleaf weed control in corn, soybean, peanuts, sorghum, and cotton. It is also used in combination with other herbicides. It been detected in ground and surface waters and concentrations ranging from 0.08 to 4.5 parts per billion (ppb) throughout the U.S. Evidence of the bioaccumulation of metolachlor in edible species of fish as well as its adverse effect on the growth and development raise concerns on its effects on human health. (L913).

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  Exposure Routes

These are the Exposure Routes we have so far for this substance. There are almost certainly more. We update this section regularly. The number of chemicals with 2 or more nastiness attributes in an exposure route is shown in orange. They grey badge shows the total amount of chemicals within the exposure route.

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