Toxno Substance Profile
Evidence-based data. We have more than 25,000 profiles on Toxno.
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Substance Name

Identification Number: CASRN | 10605-21-7

  Substance Attributes

  • Metabolic Interference or Disruption

    Interferes with human metabolism. This can be a very serious thing. Some of these interference mechanics are well established. However, often long term effects and health consequences remain largely unknown. Additionally an emerging area of concern and one that is not currently studied, is the combined synergistic effects these metabolically disrupting chemicals have on human health.

    Metabolic interference happens when the substance produces highly reactive and often damaging intermediates during detoxification or when the substance binds to specific enzymes, important structural groups on molecules, receptors and membranes or targets DNA or mimics key nutrients.

  • Exposure Produces Health Symptoms

    Symptoms maybe short term or long term depending on the exposure duration and intensity and effects areas like Cardiovascular, Gastrointestinal, Cognition, Fatigue. A substance with this attribute may cause an allergic skin reaction, serious eye irritation, allergy or asthma symptoms or breathing difficulties if inhaled.

  • Toxic to Wildlife

    May kill plants, fish, birds or other animals and insects or may be very toxic to aquatic life with long lasting effects. This then effects delicate environmental ecology and food supply in ways we don't fully understand yet.

These attributes are ONLY based on peer-reviewed evidence. See link to Data Sources below. Everyone benefits from knowing this stuff. Please Share.

  • CATEGORIES: Pesticide | Food Toxin | Synthetic Toxin | PESTICIDE active ingredient | organic | fungicide | Pesticide or Plant Growth Regulator Approved in Australia | Pesticide approved in USA (California) | A Hazardous Substance that may be found in the Australian Workplace
  • SUBSTANCE LINEAGE: Organic Compounds | Heterocyclic Compounds | Benzimidazoles | | Benzimidazoles
  • SYNONYMS: 1H-Benzimidazol-2-yl-carbamic acid | methyl ester | 1H-Benzimidazol-2-ylcarbamic acid methyl ester | 1H-Benzimidazol-2-ylcarbamic acid | methyl ester | 1H-Benzimidazole-2-carbamic acid | methyl ester | 2-(Carbomethoxyamino)benzimidazole | 2-(Methoxy-carbonylamino)-benzimidazol | 2-(Methoxycarbamoyl)benzimidazole | 2-(Methoxycarbonylamino)-benzimidazole | 2-(Methoxycarbonylamino)benzimidazole | 2-(Methoxycarboxamido)benzimidazole | 2-Benzimidazolecarbamic acid | methyl ester | 2-Bezimidazolecarbamic acid methyl ester | 2-MBC | 2-Methyl benzimidazolecarbamate | 2-[(Methoxycarbonyl)amino]benzimidazole | A 118 (Pesticide) | Agrizim | Antibac MF | Battal | Bavistan | Bavistin | Bavistin 25SD | Bavistin 3460 | Bavistin 50SD | Bavistin FL | Bavistine | BCM | BCM (fungicide) | Bengard | Benzimidazole carbamate de methyle | Benzimidazole-2-carbamic acid | methyl ester | Benzimidazolecarbamate methyl ester | Benzimidazolecarbamic | Bercema-bitosen | Bitosen | BMC | BMC? | BMK | BMK (fungicide) | Carbamic acid | 1H-benzimidazol-2-yl- | methyl ester | Carbamic acid | 1H-benzimidazolyl- | methyl ester | Carbamic acid | N-1H-benzimidazol-2-yl- | methyl ester | Carben VL | Carbendazime | Carbendazin | Carbendazine | Carbendazol | Carbendazol | JMAF | Carbendazole | Carbendazym | Carbendazyme | Custos | Delsene | Delsene 10 | Derosal | Derosal 60PM | Equitdazin | Falicarben | Funaben | Funaben 3 | Funaben 50 | Fungisol | Fungoxan | Garbenda | Ipo y | Jkatein | Jkstein | Karben | Karben flo stefes | Karben stefes flo | Kemdazin | Kid pest project (carbendazim) (see also carbendazim) | Kolfugo | Kolfugo 25 FW | Kolfugo 25FW | Kolfugo extra | MBC | Mecarzole | Medamine | Mekarzole | Methoxybenzimidazole-2-carbamic acid | Methyl 1H-benzimidazol-2-ylcarbamate | Methyl 1H-benzimidazol-2-ylcarbamate (9CI) | Methyl 1H-benzimidazol-2-ylcarbamate | 9CI | Methyl 1H-benzimidazole-2-carbamate | Methyl 1H-benzimidazolylcarbamate | Methyl 2-benzimidazil carbamate | Methyl 2-benzimidazolecarbamate | Methyl 2-benzimidazolylcarbamate | Methyl benzimidazol-2-ylcarbamate | Methyl benzimidazolecarbamate | Methyl benzimidazolylcarbamate | Methyl N-2-benzimidazolecarbamate | Methyl-2-benzimidazole carbamate | Methyl-N-(2-benzimidazolyl)carbamate | Methylbenzimidazole-2-ylcarbamate | MYCO | Olgin | Olgin (fungicide) | Pillarstin | Preparation G 665 | Preventol BCM | Protek | Sarfun | SPIN | Spin (pesticide) | Stein | Stempor | Subeej | Supercarb | Thicoper | Triticol | Zhiweiling
  • DESCRIPTION: Carbendazim is a widely used, broad-spectrum benzimidazole fungicide. It is also a metabolite of benomyl (another widely used fungicide). It is also employed as a casting worm control agent in amenity turf situations such as golf greens and tennis courts. Carbendazim is used to control plant diseases in cereals and fruits, including citrus, bananas, strawberries, pineapples, and pomes. It is also used in Queensland, Australia on macadamia plantations. Carbendazim is absorbed through the roots and green tissues. It acts by inhibiting beta-tubulin synthesis, inhibiting development of germ tubes and the growth of mycelia. It is compatible with most of the insecticides. It is used for the control of blast, sheath blight, brown spot, powdery mildew, scab, anthracnose and leaf spot diseases in various crops. The primary source of carbendazim exposure for the public at large is dietary intake.
  • COMMENTS: Residues of this pesticide are tested for on Australian Foods | Pesticide approved in Australia

    From Safe Work Australia and the Hazardous Substances Information System (HSIS) in Australia:

    May cause genetic defects. May damage fertility. May damage the unborn child. Very toxic to aquatic life with long lasting effects. | Chronic Health Hazard Environmental Hazard | A Hazardous Substance that may be found in the Australian Workplace. Check with your employer or health and safety officer. Stay informed and become aware of the dangers that surround you. This chemical is included on the list of recognised hazardous chemicals from the Safe Work Australia - Hazardous Substances Information System (HSIS) that is based on the Globally Harmonised System of Classification and Labelling of Chemicals (GHS)

    Work Health and Safety (WHS) Regulations are the basis for hazardous chemicals regulations in Commonwealth, State and Territory jurisdictions in Australia. Under the model WHS Regulations, manufacturers and importers of substances, mixtures and articles supplied for use in workplaces are required to determine whether they are hazardous to health and safety before supply. The model WHS Regulations mandate that the hazards of a chemical as determined by the Globally Harmonised System of Classification and Labelling of Chemicals (GHS) must be included in safety data sheets and on labels. There are transitional arrangements in place for moving to the GHS-based system.

    The GHS Hazardous Chemical Information List contains chemicals classified by an authoritative source (such as the European Commission or NICNAS) in accordance with the Globally Harmonized System of Classification and Labelling of Chemicals (the GHS). This list contains the vast majority of chemicals currently in HSIS. This list and its detail are regularly updated by Work Safe Australia. The model Work Health and Safety (WHS) Regulations require chemicals to be classified in accordance with the Globally Harmonised System of Classification and Labelling of Chemicals (GHS). However transitional arrangements allow use of classification information in HSIS derived from the Approved Criteria until the 31 December 2016.
  • toxin chemical structure pubchem
  • DATA SOURCES: DATA SOURCES: T3DB | PubChem | Consolidated Pesticide Information Dataset (CPI) from the USA EPA | Compendium of Pesticide Common Names | APVMA | DPR | Safe Work Australia - Hazardous Substances Information System (HSIS)
  • LAST UPDATE: 28/04/2018

  Health Associations

Mostly focused on Health Implications of Long Term Exposure to this substance

  • SYMPTOMS: Skin redness and skin irritation. Fetuses exposed to high levels may exhibit microphthalmia (small eyes) or anaphthalmia (no eyes).
  • POSSIBLE HEALTH CONSEQUENCES: Carbendazim is a suspected endocrine disruptor. It is also a developmental toxin. Animals exposed to carbendazim in the womb to have serious deformities such as lack of eyes and hydrocephalus (water on the brain). Carbendazim can disrupt the development of sperm and damage testicular development in adult rats. | The carbamates are hydrolyzed enzymatically by the liver; degradation products are excreted by the kidneys and the liver. (L793)
  • ACTION OF TOXIN: Carbendazim targets beta tubulin in actively dividing cells. It binds to microtubules, interfering with cell functions, such as meiosis and intracellular transportation (A15332). |
  • TOXIN SITES OF ACTION IN CELL: "Cytoplasm", "Extracellular", "Membrane"
  • Additional Exposure Routes: It is a systemic fungicide that is selectively toxic to microorganisms and invertebrates. It is also employed as a casting worm control agent in amenity turf situations such as golf greens and tennis courts. It is also used to control plant diseases in cereals and fruits, including citrus, bananas, strawberries, pineapples, and pomes.

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  Exposure Routes

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