Toxno Substance Profile
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Substance Name

Angelicin
Identification Number: CASRN | 523-50-2

  Substance Attributes


  • Carcinogenic Properties

    Accumulating evidence points to cancer potential. Exercise caution with this substance, explore your exposure routes and consider complete avoidance. See further details under Toxins.

  • Metabolic Interference or Disruption

    Interferes with human metabolism. This can be a very serious thing. Some of these interference mechanics are well established. However, often long term effects and health consequences remain largely unknown. Additionally an emerging area of concern and one that is not currently studied, is the combined synergistic effects these metabolically disrupting chemicals have on human health.


    Metabolic interference happens when the substance produces highly reactive and often damaging intermediates during detoxification or when the substance binds to specific enzymes, important structural groups on molecules, receptors and membranes or targets DNA or mimics key nutrients.

  • Exposure Produces Health Symptoms

    Symptoms maybe short term or long term depending on the exposure duration and intensity and effects areas like Cardiovascular, Gastrointestinal, Cognition, Fatigue. A substance with this attribute may cause an allergic skin reaction, serious eye irritation, allergy or asthma symptoms or breathing difficulties if inhaled.

These attributes are ONLY based on peer-reviewed evidence. See link to Data Sources below. Everyone benefits from knowing this stuff. Please Share.



  • CATEGORIES: Plant Toxin | Food Toxin | Natural Toxin
  • SUBSTANCE LINEAGE: Organic Compounds | Phenylpropanoids and Polyketides | Coumarins and Derivatives | Furanocoumarins | Furanocoumarins
  • SYNONYMS: 2H-Furo[2,3-H]-1-benzopyran-2-one | 2H-Furo[2,3-H]chromen-2-one | 3-(4-Hydroxy-5-benzofuranyl)-2-propenoic acid gamma-lactone | 4-Hydroxy-5-benzofuranacrylic acid gamma-lactone | Angecin | Angelecin | Bakuchicin | Furo[2,3-h]coumarin | Furo[5',4':7,8]coumarin | Isopsoralen | Isopsoralin
  • DESCRIPTION: Angelicin is found in coriander. Angelicin is a constituent of roots and leaves of angelica (Angelica archangelica). Angelicin is found in roots and on surface of parsnips and diseased celery.Angelicin is a furanocoumarin. It can be found in Bituminaria bituminosa. It is present in the list of IARC Group 3 carcinogens (Angelicin plus ultraviolet A radiation). (Wikipedia).
  • COMMENTS:
  • toxin chemical structure pubchem
  • FORMULA: C11H6O3
  • DATA SOURCES: DATA SOURCES: T3DB | PubChem | IARC
  • LAST UPDATE: 28/04/2018

  Health Associations

Mostly focused on Health Implications of Long Term Exposure to this substance

  • SYMPTOMS: Harmful by inhalation, in contact with skin and if swallowed. Irritating to eyes, respiratory system and skin. (L579)
  • POSSIBLE HEALTH CONSEQUENCES: Furocoumarins can cause photosensitization dermatitis especially if these compounds come into contact with the skin. Some furocoumarins, especially bifunctional furocoumarins, are known to be carcinogenic (A15105). Furocoumarin photochemotherapy is known to induce a number of side-effects including erythema, edema, hyperpigmentation, and premature aging of skin. All photobiological effects of furocoumarins result from their photochemical reactions. Because many dietary or water soluble furocoumarins are strong inhibitors of cytochrome P450s, they will also cause adverse drug reactions when taken with other drugs. Limited evidence of carcinogenic effect. (L579) |
  • ACTION OF TOXIN: The mechanism of action many furocoumarins is based on their ability to form photoadducts with DNA and other cellular components such as RNA, proteins, and several proteins found in the membrane such as phospholipases A2 and C, Ca-dependent and cAMPdependent protein-kinase and epidermal growth factor. Furocoumarins intercalate between base pairs of DNA and after ultraviolet-A irradiation, giving cycloadducts. (L579) | Upon long wavelength UV irradiation, forms monoadduct with double-stranded DNA and react with unsaturated fatty acids. Inhibits DNA and RNA synthesis and cell replication in Ehrlich ascites tumor cells. (L579)
  • TOXIN SITES OF ACTION IN CELL: "Cytoplasm", "Extracellular"
  • Additional Exposure Routes: Angelicin is used as tranquilliser, sedative, or anticonvulsant. (L579)

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  Exposure Routes

These are the Exposure Routes we have so far for this substance. There are almost certainly more. We update this section regularly. The number of chemicals with 2 or more nastiness attributes in an exposure route is shown in orange. They grey badge shows the total amount of chemicals within the exposure route.


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