Toxno Substance Profile
Evidence-based data. We have more than 25,000 profiles on Toxno.
Use Search below to seek out more. Or browse the Exposure Routes; alternatively see our Lists that have more substances than notes in a Liszt virtuoso piano piece.
Substance Name

Clotrimazole
Identification Number: CASRN | 23593-75-1

  Substance Attributes


  • Metabolic Interference or Disruption

    Interferes with human metabolism. This can be a very serious thing. Some of these interference mechanics are well established. However, often long term effects and health consequences remain largely unknown. Additionally an emerging area of concern and one that is not currently studied, is the combined synergistic effects these metabolically disrupting chemicals have on human health.


    Metabolic interference happens when the substance produces highly reactive and often damaging intermediates during detoxification or when the substance binds to specific enzymes, important structural groups on molecules, receptors and membranes or targets DNA or mimics key nutrients.

  • Exposure Produces Health Symptoms

    Symptoms maybe short term or long term depending on the exposure duration and intensity and effects areas like Cardiovascular, Gastrointestinal, Cognition, Fatigue. A substance with this attribute may cause an allergic skin reaction, serious eye irritation, allergy or asthma symptoms or breathing difficulties if inhaled.

  • Has known Side Effects

    This is often the result of long or short term medication use. The same medication can have a range of side effects ranging from none at all to totally debilitating symptoms within different individuals. Reasons for this include individual genetics, individual detoxification capacity, nutrition status, duration of use and total number of medications being taken.


    It becomes very difficult to establish clear causes of symptoms when multiple medications are being taken at once.


    See SIDE EFFECTS LINKOUT at end of this profile.

These attributes are ONLY based on peer-reviewed evidence. See link to Data Sources below. Everyone benefits from knowing this stuff. Please Share.



  • CATEGORIES: Medication or Drug | Food Toxin | Synthetic Toxin | PESTICIDE active ingredient | organic | other | Pesticide or Plant Growth Regulator Approved in Australia | A Hazardous Substance that may be found in the Australian Workplace | Medication Approved in Australian (on the PBS) | Medication Approved in USA
  • SUBSTANCE LINEAGE: Organic Compounds | Benzenoids | Benzene and Substituted Derivatives | Halobenzenes | Chlorobenzenes
  • SYNONYMS: (Chlorotrityl)imidazole | 1-((2-Chlorophenyl)diphenylmethyl)-1H-imidazole | 1-(alpha-(2-Chlorophenyl)benzhydryl)imidazole | 1-(O-Chloro-alpha,alpha-diphenylbenzyl)imidazole | 1-(o-Chloro-α,α-diphenylbenzyl)imidazole | 1-(O-Chlorotrityl)imidazole | 1-(α-(2-Chlorophenyl)benzhydryl)imidazole | Canesten | Canesten 1-Day Cream Combi-Pak | Canesten 1-Day Therapy | Canesten 3-Day Therapy | Canesten 6-Day Therapy | Canesten Combi-Pak 1-Day Therapy | Canesten Combi-Pak 3-Day Therapy | Canesten Cream | Canesten Solution | Canestine | Canifug | Chlotrimazole | Clotrimaderm | Clotrimaderm Cream | Clotrimazol | Clotrimazolum | Desamix F | Empecid | Fem Care | FemCare | Fungicip | Gyne lotrimin | Gyne-lotrimin | Gyne-Lotrimin 3 | Gyne-Lotrimin 3 Combination Pack | Gyne-Lotrimin Combination Pack | Gyne-Lotrimin3 | Gyne-Lotrimin3 Combination Pack | Gynix | Lopac-C-6019 | Lotrimax | Lotrimin | Lotrimin AF | Lotrimin AF Cream | Lotrimin AF Jock-Itch Cream | Lotrimin AF Lotion | Lotrimin AF Solution | Lotrimin Cream | Lotrimin Lotion | Lotrimin Solution | Lotrisone | Mono-baycuten | Monobaycuten | Mycelax | Mycelex | Mycelex 7 | Mycelex Cream | Mycelex G | Mycelex OTC | Mycelex Solution | Mycelex Troches | Mycelex Twin Pack | Mycelex-7 | Mycelex-7 Combination Pack | Mycelex-G | Mycelex: MycosporinRimazole | Myclo Cream | Myclo Solution | Myclo Spray Solution | Myclo-Derm | Myclo-Gyne | Mycosporin | Mykosporin | Neo-Zol Cream | Otomax | Pedisafe | Prestwick_120 | Rimazole | Tibatin | Trimysten | Trivagizole 3 | Veltrim
  • DESCRIPTION: Clotrimazole is an imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal cell membranes. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane. There is the potential for drug interactions with Clotrimazole if taken orally, as it is a potent, specific inhibitor of cytochrome P450 oxidase enzymes and so may alter the metabolism of other drugs. Clotrimazole is an antifungal medication commonly used in the treatment of fungal infections of both humans and animals such as vaginal yeast infections and ringworm. An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal cell membranes. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane. Clotrimazole is a potent, specific inhibitor of cytochrome P450 oxidase enzymes. Hence, it may alter the metabolism of other drugs particularly if taken orally. Clotrimazole is an antifungal medication commonly used in the treatment of fungal infections of both humans and animals such as vaginal yeast infections and ringworm. It also used to treat athlete's foot and jock itch.
  • COMMENTS: Residues of this pesticide are NOT tested for on Australian Foods even though the Pesticide is approved in Australia. This is partly so because this pesticide is not usually used around food agriculture. | Pesticide approved in Australia

    From Safe Work Australia and the Hazardous Substances Information System (HSIS) in Australia:

    | | A Hazardous Substance that may be found in the Australian Workplace. Check with your employer or health and safety officer. Stay informed and become aware of the dangers that surround you. This chemical is included on the list of recognised hazardous chemicals from the Safe Work Australia - Hazardous Substances Information System (HSIS) that is based on the Globally Harmonised System of Classification and Labelling of Chemicals (GHS)

    Work Health and Safety (WHS) Regulations are the basis for hazardous chemicals regulations in Commonwealth, State and Territory jurisdictions in Australia. Under the model WHS Regulations, manufacturers and importers of substances, mixtures and articles supplied for use in workplaces are required to determine whether they are hazardous to health and safety before supply. The model WHS Regulations mandate that the hazards of a chemical as determined by the Globally Harmonised System of Classification and Labelling of Chemicals (GHS) must be included in safety data sheets and on labels. There are transitional arrangements in place for moving to the GHS-based system.

    The GHS Hazardous Chemical Information List contains chemicals classified by an authoritative source (such as the European Commission or NICNAS) in accordance with the Globally Harmonized System of Classification and Labelling of Chemicals (the GHS). This list contains the vast majority of chemicals currently in HSIS. This list and its detail are regularly updated by Work Safe Australia. The model Work Health and Safety (WHS) Regulations require chemicals to be classified in accordance with the Globally Harmonised System of Classification and Labelling of Chemicals (GHS). However transitional arrangements allow use of classification information in HSIS derived from the Approved Criteria until the 31 December 2016.
  • toxin chemical structure pubchem
  • FORMULA: C22H17ClN2
  • DATA SOURCES: DATA SOURCES: ARTICLE 4 | T3DB | PubChem | Consolidated Pesticide Information Dataset (CPI) from the USA EPA | Compendium of Pesticide Common Names | APVMA | Safe Work Australia - Hazardous Substances Information System (HSIS) | Drugbank | Australian Approved Medications PBS | USA FDA APPROVED DRUG PRODUCTS
  • LAST UPDATE: 28/04/2018

  Health Associations

Mostly focused on Health Implications of Long Term Exposure to this substance

  • SYMPTOMS: Symptoms of overdose include erythema, stinging, blistering, peeling, edema, pruritus, urticaria, burning, and general irritation of the skin, and cramps.
  • POSSIBLE HEALTH CONSEQUENCES: | Hepatic (metabolized to inactive metabolites) Half Life: 2 hours
  • ACTION OF TOXIN: Clotrimazole interacts with yeast 14-α demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol, an essential component of the membrane. In this way, clotrimazole inhibits ergosterol synthesis, resulting in increased cellular permeability. Clotrimazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms and the uptake of purine, impair triglyceride and/or phospholipid biosynthesis, and inhibit the movement of calcium and potassium ions across the cell membrane by blocking the ion transport pathway known as the Gardos channel. | Clotrimazole interacts with yeast 14-α demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol, an essential component of the membrane. In this way, clotrimazole inhibits ergosterol synthesis, resulting in increased cellular permeability. Clotrimazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms and the uptake of purine, impair triglyceride and/or phospholipid biosynthesis, and inhibit the movement of calcium and potassium ions across the cell membrane by blocking the ion transport pathway known as the Gardos channel.
  • TOXIN SITES OF ACTION IN CELL: "Membrane"
  • Additional Exposure Routes: For the local treatment of oropharyngeal candidiasis and vaginal yeast infections, also used in fungal infections of the skin such as ringworm, athlete's foot, and jock itch.
  • SEE MEDICATION SIDE EFFECTS

 Search all of Toxno

Or browse our mind blowing but terrifying Lists.

  Exposure Routes

These are the Exposure Routes we have so far for this substance. There are almost certainly more. We update this section regularly. The number of chemicals with 2 or more nastiness attributes in an exposure route is shown in orange. They grey badge shows the total amount of chemicals within the exposure route.


  Stay Informed

Chemicals released in consumer products and the environment are constantly changing. Regulations change. Exposure Routes change. People speak up and nasties are removed while often others are introduced.

By signing up you will periodically receive updates of potentially life changing information. Both for yourself and your family.

We take security and privacy very seriously and you can unsubscribe at any time.


cats at toxno

"Yeh. We were surprised too"