Toxno Substance Profile
Evidence-based data. We have more than 25,000 profiles on Toxno.
Use Search below to seek out more. Or browse the Exposure Routes; alternatively see our Lists that have more substances than notes in a Liszt virtuoso piano piece.
Substance Name

Lead nitrate
Identification Number: CASRN | 10099-74-8

  Substance Attributes


  • Neurotoxic Properties

    Negative impact on brain and nervous system.

  • Metabolic Interference or Disruption

    Interferes with human metabolism. This can be a very serious thing. Some of these interference mechanics are well established. However, often long term effects and health consequences remain largely unknown. Additionally an emerging area of concern and one that is not currently studied, is the combined synergistic effects these metabolically disrupting chemicals have on human health.


    Metabolic interference happens when the substance produces highly reactive and often damaging intermediates during detoxification or when the substance binds to specific enzymes, important structural groups on molecules, receptors and membranes or targets DNA or mimics key nutrients.

  • Exposure Produces Health Symptoms

    Symptoms maybe short term or long term depending on the exposure duration and intensity and effects areas like Cardiovascular, Gastrointestinal, Cognition, Fatigue. A substance with this attribute may cause an allergic skin reaction, serious eye irritation, allergy or asthma symptoms or breathing difficulties if inhaled.

These attributes are ONLY based on peer-reviewed evidence. See link to Data Sources below. Everyone benefits from knowing this stuff. Please Share.



  • CATEGORIES: Pesticide | Pollutant | Airborne Pollutant | Synthetic Toxin
  • SUBSTANCE LINEAGE: Inorganic Compounds | Mixed Metal/Non-metal Compounds | Miscellaneous Mixed Metal/Non-metals | Miscellaneous Metallic Oxoanionic Compounds | Miscellaneous Plumbites
  • SYNONYMS: lead (2+) nitrate | Lead dinitrate | Lead nitrate (Pb(NO3)2) | lead nitrate | 210Pb(2+)-labeled | Lead nitric acid | Lead(2+) nitrate | Plumbous nitrate | [Pb(NO3)2]
  • DESCRIPTION: Lead nitrate is a nitrate of lead produced synthetically by dissolving metallic lead or lead(II) oxide in nitric acid. It is an oxidizing agent and is used to make other lead compounds. It is also used as a heat stabiliser in nylon and polyesters, as a coating for photothermographic paper, and in rodenticides. Lead is a heavy metal and stable element with the symbol Pb and the atomic number 82, existing in metallic, organic, and inorganic forms. It is mainly found in nature as the mineral galena (PbS), cerussite (PbCO3) or anglesite (PbSO4), usually in ore with zinc, silver, or copper. Nitrite is a toxic compound known to cause methemoglobinemia. (L1137, L21, L411)
  • COMMENTS:
  • toxin chemical structure pubchem
  • FORMULA: N2O6Pb
  • DATA SOURCES: DATA SOURCES: T3DB | PubChem
  • LAST UPDATE: 28/04/2018

  Health Associations

Mostly focused on Health Implications of Long Term Exposure to this substance

  • SYMPTOMS: Symptions of chronic lead poisoning include reduced cognitive abilities, nausea, abdominal pain, irritability, insomnia, metal taste in the mouth, excess lethargy or hyperactivity, chest pain, headache and, in extreme cases, seizures, comas, and death. There are also associated gastrointestinal problems, such as constipation, diarrhea, vomiting, poor appetite, weight loss, which are common in acute poisoning. Nitrate and nitrite poisoning causes methemoglobinemia. Symptoms include cyanosis, cardiac dysrhythmias and circulatory failure, and progressive central nervous system (CNS) effects. CNS effects can range from mild dizziness and lethargy to coma and convulsions. (L1137, A2, L21)
  • POSSIBLE HEALTH CONSEQUENCES: Lead is a neurotoxin and has been known to cause brain damage and reduced cognitive capacity, especially in children. Lead exposure can result in nephropathy, as well as blood disorders such as high blood pressure and anemia. Lead also exhibits reproductive toxicity and can results in miscarriages and reduced sperm production. Nitrate and nitrite poisoning causes methemoglobinemia. Nitrites may cause pregnancy complications and developmental effects. They may also be carcinogenic. (L1137, L21) | Lead is absorbed following inhalation, oral, and dermal exposure. It is then distributed mainly to the bones and red blood cells. In the blood lead may be found bound to serum albumin or the metal-binding protein metallothionein. Organic lead is metabolized by cytochrome P-450 enzymes, whereas inorganic lead forms complexes with delta-aminolevulinic acid dehydratase. Lead is excreted mainly in the urine and faeces. Intake of some amount of nitrates and nitrites is a normal part of the nitrogen cycle in humans. In vivo conversion of nitrates to nitrites can occur in the gastrointestional tract under the right conditions, significantly enhancing nitrates' toxic potency. The major metabolic pathway for nitrate is conversion to nitrite, and then to ammonia. Nitrites, nitrates, and their metabolites are excreted in the urine. (L1137, L136)
  • ACTION OF TOXIN: Lead mimics other biologically important metals, such as zinc, calcium, and iron, competing as cofactors for many of their respective enzymatic reactions. For example, lead has been shown to competitively inhibit calcium's binding of calmodulin, interferring with neurotransmitter release. It exhibits similar competitive inhibition at the NMDA receptor and protein kinase C, which impairs brain microvascular formation and function, as well as alters the blood-brain barrier. Lead also affects the nervous system by impairing regulation of dopamine synthesis and blocking evoked release of acetylcholine. However, it's main mechanism of action occurs by inhibiting delta-aminolevulinic acid dehydratase, an enzyme vital in the biosynthesis of heme, which is a necesssary cofactor of hemoglobin. Nitrate's toxicity is a result of it's conversion to nitrite once in the body. Nitrite causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and methemoglobin. This elevation of methemoglobin levels is a condition known as methemoglobinemia, and is characterized by tissue hypoxia, as methemoglobin cannot bind oxygen. (A2450, L1613, T4, A20, A22, L136) | Lead is known to bind ACBP, which is responsible for the regulation of various processes such as acyl-CoA metabolism, GABA-A/benzodiazepine receptor modulation, steroidogenesis, intestinal cholecystokinin release, and insulin secretion. (A21)
  • TOXIN SITES OF ACTION IN CELL: "Cytoplasm", "Extracellular"
  • Additional Exposure Routes: Lead nitrate is used as a heat stabiliser in nylon and polyesters, as a coating for photothermographic paper, in rodenticides, and in gold cyanidation. (L411)

 Search all of Toxno

Or browse our mind blowing but terrifying Lists.

  Exposure Routes

These are the Exposure Routes we have so far for this substance. There are almost certainly more. We update this section regularly. The number of chemicals with 2 or more nastiness attributes in an exposure route is shown in orange. They grey badge shows the total amount of chemicals within the exposure route.


      Stay Informed

    Chemicals released in consumer products and the environment are constantly changing. Regulations change. Exposure Routes change. People speak up and nasties are removed while often others are introduced.

    By signing up you will periodically receive updates of potentially life changing information. Both for yourself and your family.

    We take security and privacy very seriously and you can unsubscribe at any time.


    cats at toxno

    "Yeh. We were surprised too"