Toxno Substance Profile
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Substance Name

Biotin
Identification Number: CASRN | 58-85-5

  Substance Attributes


  • Exposure Produces Health Symptoms

    Symptoms maybe short term or long term depending on the exposure duration and intensity and effects areas like Cardiovascular, Gastrointestinal, Cognition, Fatigue. A substance with this attribute may cause an allergic skin reaction, serious eye irritation, allergy or asthma symptoms or breathing difficulties if inhaled.

  • Has known Side Effects

    This is often the result of long or short term medication use. The same medication can have a range of side effects ranging from none at all to totally debilitating symptoms within different individuals. Reasons for this include individual genetics, individual detoxification capacity, nutrition status, duration of use and total number of medications being taken.


    It becomes very difficult to establish clear causes of symptoms when multiple medications are being taken at once.


    See SIDE EFFECTS LINKOUT at end of this profile.

These attributes are ONLY based on peer-reviewed evidence. See link to Data Sources below. Everyone benefits from knowing this stuff. Please Share.



  • CATEGORIES: Medication or Drug | Household Toxin | Food Toxin | Natural Toxin | Animal Toxin | EAFUS (Everything Added to Food in the United States) | Inert Pesticide Ingredient USA - Non Food Use Only
  • SUBSTANCE LINEAGE: Organic Compounds | Heterocyclic Compounds | Biotin and Derivatives | | Biotin and Derivatives
  • SYNONYMS: (+)-Biotin | (+)-cis-Hexahydro-2-oxo-1H-thieno[3,4]imidazole-4-valerate | (+)-cis-Hexahydro-2-oxo-1H-thieno[3,4]imidazole-4-valeric acid | (3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-D]imidazole-4-valerate | (3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-D]imidazole-4-valeric acid | -(+)-biotin | 1swk | 1swn | 1swr | 5-(2-Oxohexahydro-1H-thieno[3,4-D]imidazol-4-yl)pentanoate | 5-(2-Oxohexahydro-1H-thieno[3,4-D]imidazol-4-yl)pentanoic acid | Appearex | Biodermatin | Bioepiderm | Bios h | Bios II | Biotin Forte | Biotina | Biotine | Biotinum | cis-(+)-Tetrahydro-2-oxothieno[3,4]imidazoline-4-valerate | cis-(+)-Tetrahydro-2-oxothieno[3,4]imidazoline-4-valeric acid | cis-Hexahydro-2-oxo-1H-thieno(3,4)imidazole-4-valeric acid | cis-Tetrahydro-2-oxothieno(3,4-D)imidazoline-4-valeric acid | Coenzyme R | D(+)-Biotin | D-(+)-Biotin | D-Biotin | D-Biotin factor S | delta-(+)-Biotin | delta-Biotin | delta-Biotin factor S | Factor S | Factor S (vitamin) | Hexahydro-2-oxo-1H-thieno(3,4-D)imidazole-4-pentanoate | Hexahydro-2-oxo-1H-thieno(3,4-D)imidazole-4-pentanoic acid | Hexahydro-2-oxo-[3aS-(3aa,4b,6aa)]-1H-Thieno[3,4-D]imidazole-4-pentanoate | Hexahydro-2-oxo-[3aS-(3aa,4b,6aa)]-1H-Thieno[3,4-D]imidazole-4-pentanoic acid | Hexahydro-2-oxo-[3as-(3alpha,4beta,6alpha)]-1H-Thieno[3,4-D]imidazole-4-pentanoate | Hexahydro-2-oxo-[3as-(3alpha,4beta,6alpha)]-1H-Thieno[3,4-D]imidazole-4-pentanoic acid | Lutavit H2 | Meribin | Nail-ex | Rovimix H 2 | Vitamin B7 | Vitamin H | Vitamin-h
  • DESCRIPTION: Biotin is an enzyme co-factor present in minute amounts in every living cell. Biotin is also known as vitamin H or B7 or coenzyme R. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk. Biotin has been recognized as an essential nutrient. Our biotin requirement is fulfilled in part through diet, through endogenous reutilization of biotin and perhaps through capture of biotin generated in the intestinal flora. The utilization of biotin for covalent attachment to carboxylases and its reutilization through the release of carboxylase biotin after proteolytic degradation constitutes the 'biotin cycle'. Biotin deficiency is associated with neurological manifestations, skin rash, hair loss and metabolic disturbances that are thought to relate to the various carboxylase deficiencies (metabolic ketoacidosis with lactic acidosis). It has also been suggested that biotin deficiency is associated with protein malnutrition, and that marginal biotin deficiency in pregnant women may be teratogenic. Biotin acts as a carboxyl carrier in carboxylation reactions. There are four biotin-dependent carboxylases in mammals: those of propionyl-CoA (PCC), 3-methylcrotonyl-CoA (MCC), pyruvate (PC) and acetyl-CoA carboxylases (isoforms ACC-1 and ACC-2). All but ACC-2 are mitochondrial enzymes. The biotin moiety is covalently bound to the epsilon amino group of a Lysine residue in each of these carboxylases in a domain 60-80 amino acids long. The domain is structurally similar among carboxylases from bacteria to mammals. There are four biotin-dependent carboxylases in mammals: those of propionyl-CoA (PCC), 3-methylcrotonyl-CoA (MCC), pyruvate (PC) and acetyl-CoA carboxylases (isoforms ACC-1 and ACC-2). All but ACC-2 are mitochondrial enzymes. The biotin moiety is covalently bound to the epsilon amino group of a Lys residue in each of these carboxylases in a domain 60-80 amino acids long. The domain is structurally similar among carboxylases from bacteria to mammals. Evidence is emerging that biotin participates in processes other than classical carboxylation reactions. Specifically, novel roles for biotin in cell signaling, gene expression, and chromatin structure have been identified in recent years. Human cells accumulate biotin by using both the sodium-dependent multivitamin transporter and monocarboxylate transporter 1. These transporters and other biotin-binding proteins partition biotin to compartments involved in biotin signaling: cytoplasm, mitochondria, and nuclei. The activity of cell signals such as biotinyl-AMP, Sp1 and Sp3, nuclear factor (NF)-kappaB, and receptor tyrosine kinases depends on biotin supply. Consistent with a role for biotin and its catabolites in modulating these cell signals, greater than 2000 biotin-dependent genes have been identified in various human tissues. Many biotin-dependent gene products play roles in signal transduction and localize to the cell nucleus, consistent with a role for biotin in cell signaling. Posttranscriptional events related to ribosomal activity and protein folding may further contribute to effects of biotin on gene expression. Finally, research has shown that biotinidase and holocarboxylase synthetase mediate covalent binding of biotin to histones (DNA-binding proteins), affecting chromatin structure; at least seven biotinylation sites have been identified in human histones. Biotinylation of histones appears to play a role in cell proliferation, gene silencing, and the cellular response to DNA repair. Roles for biotin in cell signaling and chromatin structure are consistent with the notion that biotin has a unique significance in cell biology. (A7825, A7826).
  • COMMENTS:
  • toxin chemical structure pubchem
  • FORMULA: C10H16N2O3S
  • DATA SOURCES: DATA SOURCES: ARTICLE 4 | T3DB | PubChem | EAFUS | EPA USA - Pesticide Inerts | Drugbank
  • LAST UPDATE: 28/04/2018

  Health Associations

Mostly focused on Health Implications of Long Term Exposure to this substance

  • SYMPTOMS: Prolonged skin contact may cause irritation.
  • POSSIBLE HEALTH CONSEQUENCES:
  • ACTION OF TOXIN: Biotin is necessary for the proper functioning of enzymes that transport carboxyl units and fix carbon dioxide, and is required for various metabolic functions, including gluconeogenesis, lipogenesis, fatty acid biosynthesis, propionate metabolism, and catabolism of branched-chain amino acids. | Biotin is necessary for the proper functioning of enzymes that transport carboxyl units and fix carbon dioxide, and is required for various metabolic functions, including gluconeogenesis, lipogenesis, fatty acid biosynthesis, propionate metabolism, and catabolism of branched-chain amino acids.
  • TOXIN SITES OF ACTION IN CELL: "Cytoplasm", "Extracellular", "Mitochondria", "Nucleus"
  • Additional Exposure Routes: For nutritional supplementation, also for treating dietary shortage or imbalance.
  • SEE MEDICATION SIDE EFFECTS

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  Exposure Routes

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