Metabolic Interference or Disruption
Interferes with human metabolism. This can be a very serious thing. Some of these interference mechanics are well established. However, often long term effects and health consequences remain largely unknown. Additionally an emerging area of concern and one that is not currently studied, is the combined synergistic effects these metabolically disrupting chemicals have on human health.
Metabolic interference happens when the substance produces highly reactive and often damaging intermediates during detoxification or when the substance binds to specific enzymes, important structural groups on molecules, receptors and membranes or targets DNA or mimics key nutrients.
Exposure Produces Health Symptoms
Symptoms maybe short term or long term depending on the exposure duration and intensity and effects areas like Cardiovascular, Gastrointestinal, Cognition, Fatigue. A substance with this attribute may cause an allergic skin reaction, serious eye irritation, allergy or asthma symptoms or breathing difficulties if inhaled.
Toxic to specific organs
Can damage liver, kidney, lungs, heart or gut. Ironically liver, kidneys and gut are the main detoxifications systems.
These attributes are ONLY based on peer-reviewed evidence. See link to Data Sources below. Everyone benefits from knowing this stuff. Please Share.
- CATEGORIES: Drilling Chemicals, CSG - The information here is based on chemicals used in drilling a natural gas well, Crosby 25-3, in Park County, Wyoming. Natural gas, petroleum condensate, and drilling fluids were accidentally released from the ground adjacent to the well due to a breach in the surface casing. This occurred over a period of about 58 hours between August 11 and 13th, 2006. | Chemicals used in hydraulic fracturing fluids | Household Toxin | Industrial/Workplace Toxin | Synthetic Toxin | Indirect Additives Used in Food Contact Substances | Inert Pesticide Ingredient USA - Food Use Permitted
- SUBSTANCE LINEAGE: Inorganic Compounds | Mixed Metal/Non-metal Compounds | Alkaline Earth Metal Oxoanionic Compounds | Alkaline Earth Metal Sulfates | Alkaline Earth Metal Sulfates
- SYNONYMS: Acb Pws | Actybaryte | Anatrast Pst | Artificial barite | Artificial heavy spar | Bakontal | Bar-test | Baraflave | Baricon | Baricon for suspension | Baridol | BarII sulphas | Barite | Barite (Ba(SO4)) | Baritogen deluxe | Baritop | Baritop 100 | Baritop g powder | Baritop p | Barium 100 | Barium andreu | Barium sulfate (1:1) | Barium Sulfate (2:1) | Barium sulfate (BaSO4) | Barium sulfate (JP15/USP) | Barium sulfic acid | Barium sulfuricum | Barium sulphate | Barium sulphate | natural | Barium sulphic acid | Baro Bag Enema | Barobag | Barocat | Barocat Susp | Barodense | Baroloid | Barosperse | Barosperse 110 | Barosperse Disposable Enema Units | Barosperse for Susp | Barosperse II | Barotrast | Baryta white | Baryte | Barytes | Barytes 22 | Barytgen | Baryum (sulfate de) | Baryx colloidal | Baryxine | Basofor | Bayrites | BF 1 (salt) | BF 10 (sulfate) | Blanc fixe | C.I. Pigment White 21 | Caswell No. 071B | Cheetah | CI Pigment white 21 | Citobaryum | Colonatrast | Danobaryt | E z cat | E-z preparations | E-z-ac | E-z-cat | E-z-cat concentrate | E-Z-Cat Liq | E-z-HD | E-z-paque | E-Z-Paque Powder for Suspension | E-z-paste esophageal cream | Enamel white | Enecat | Enemark | Eneset | Enhancer | Enterovu liquid | Entrobar | Entrobar Suspension | Entroease | Epi-c | Epi-Stat 57 | Epi-Stat 61 | Esobar | Esopho-cat | Esopho-Cat Crm | Esophotrast | Esophotrast esophageal cream | Eweiss | Ezcat | Finemeal | Flo-Coat Susp | Gastropaque-s | Gel-unix | HD 200 Plus | Hd 85 Barium Sulfate Susp | Hitone | Intropaque | Intropaste - Pst Orl | Lactobaryt | Liqui-Coat Hd - Sus Orl | Liquibarine | Liquid barosperse | Liquid Barosperse- Sus Orl Rt | Liquid e-z-paque | Liquid polibar | Liquid polibar plus | Liquid sol-o-pake | Liquipake | Macropaque | Medebar Plus - Sus Orl Rt | Microbar | Microfanox | Micropaque | Micropaque oral | Micropaque RD | Microtrast | Mikabarium b | Mikabarium f | Mixobar | Mixture III | Neobalgin | Neobar | Novopaque | Oesobar | Oratrast | Permanent white | Pigment white 21 | Pigment White 22 | Polibar | Polibar Liq | Polibar plus | Polibar Rapid | Precipitated barium sulphate | Prepcat | Radimix colon | Radio-baryx | Radiobaryt | Radiopaque | Raybar | Readi-cat | Readi-CAT 2 | Recto barium | Recto-barium | Redi-flow | Rugar | Sol-o-pake | Solbar | Sparkle granules | Sulfate | barium | Sulfuric acid | barium salt (1:1) | Supramike | Suspobar | Tixobar | Tomo Cat Barium Sulfate Susp | TomoCat 1000 Concentrate | Tomocat concentrate | TonoJug 2000 | Tonopaque | Topcontral | Travad | Ultra-r | Umbrasol a | Unibar 100 Sus | Unibaryt | Unit-pak | Veri-o-pake | X-opac | Xylocaine viscous
- DESCRIPTION: Has been used in CSG, Hydraulic Fracturing Operations (Fracking) as - Weighting material, drilling additive, drilling compound NOS, unknown | Barium sulfate is a sulfate of barium. It is used as a radiocontrast agent for X-ray imaging, in pigments, and to produce green light in pyrotechnics. Barium is a metallic alkaline earth metal with the symbol Ba, and atomic number 56. It never occurs in nature in its pure form due to its reactivity with air, but combines with other chemicals such as sulfur or carbon and oxygen to form barium compounds that may be found as minerals. (L214, 408, L210)
- FORMULA: BaO4S
- DATA SOURCES: DATA SOURCES: ARTICLE 4 | T3DB | PubChem | Article-Colborn-2010 | US HOUSE OF REPRESENTATIVES | FDA Indirect Food Additives | EPA USA - Pesticide Inerts
- LAST UPDATE: 28/04/2018
Mostly focused on Health Implications of Long Term Exposure to this substance
- SYMPTOMS: Ingesting excess barium may cause vomiting, abdominal cramps, diarrhea, difficulties in breathing, increased or decreased blood pressure, numbness around the face, and muscle weakness. High levels may result in changes in heart rhythm or paralysis and possibly death. (L214)
- POSSIBLE HEALTH CONSEQUENCES: The health effects of the different barium compounds depend on how well the compound dissolves in water or the stomach contents. At low doses, barium acts as a muscle stimulant, while higher doses affect the nervous system, causing cardiac irregularities, tremors, weakness, anxiety, dyspnea, paralysisand possibly death. Barium may also cause gastrointestinal disturbances, damage the kidneys and cause decreases in body weight. (L214) | Barium compounds are absorbed via ingestion and inhalation, the extent of which depends on the individual compound. In the body, the majority of the barium is found in the bone, while small amounts exists in the muscle, adipose, skin, and connective tissue. Barium is not metabolized in the body, but it may be transported or incorporated into complexes or tissues. Barium is excreted in the urine and faeces. (L214)
- ACTION OF TOXIN: Barium is a competitive potassium channel antagonist that blocks the passive efflux of intracellular potassium, resulting in a shift of potassium from extracellular to intracellular compartments. The intracellular translocation of potassium results in a decreased resting membrane potential, making the muscle fibers electrically unexcitable and causing paralysis. Some of these barium's effects may also be due to barium induced neuromuscular blockade and membrane depolarization. (L214) | Barium is a competitive antagonist at inward rectifier potassium channels and blocks the passive efflux of intracellular potassium, resulting in a shift of potassium from extracellular to intracellular compartments. The intracellular translocation of potassium results in a decreased resting membrane potential, making the muscle fibers electrically unexcitable and causing paralysis. (A150)
- TOXIN SITES OF ACTION IN CELL: "Cytoplasm", "Extracellular"
- Additional Exposure Routes: Barium sulfate is used as a radiocontrast agent for X-ray imaging, in pigments, and to produce green light in pyrotechnics. (L210)
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