Metabolic Interference or Disruption
Interferes with human metabolism. This can be a very serious thing. Some of these interference mechanics are well established. However, often long term effects and health consequences remain largely unknown. Additionally an emerging area of concern and one that is not currently studied, is the combined synergistic effects these metabolically disrupting chemicals have on human health.
Metabolic interference happens when the substance produces highly reactive and often damaging intermediates during detoxification or when the substance binds to specific enzymes, important structural groups on molecules, receptors and membranes or targets DNA or mimics key nutrients.
Exposure Produces Health Symptoms
Symptoms maybe short term or long term depending on the exposure duration and intensity and effects areas like Cardiovascular, Gastrointestinal, Cognition, Fatigue. A substance with this attribute may cause an allergic skin reaction, serious eye irritation, allergy or asthma symptoms or breathing difficulties if inhaled.
These attributes are ONLY based on peer-reviewed evidence. See link to Data Sources below. Everyone benefits from knowing this stuff. Please Share.
- CATEGORIES: Chemical used in hydraulic fracturing fluids | Household Toxin | Synthetic Toxin | Indirect Additives Used in Food Contact Substances | Inert Pesticide Ingredient USA - Food Use Permitted
- SUBSTANCE LINEAGE: Organic Compounds | Organic Acids and Derivatives | Organic Sulfuric Acids and Derivatives | Sulfuric Acid Esters | Sulfuric Acid Monoesters
- SYNONYMS: Ammonium dodecyl sulfate | Ammonium lauryl sulfate solution | Ammonium lauryl sulfic acid | Ammonium lauryl sulphate | Ammonium lauryl sulphic acid | Dodecyl sulfate ammonium salt
- DESCRIPTION: Has been used in CSG, Hydraulic Fracturing Operations (Fracking) as - Unknown | Ammonium lauryl sulfate (ALS) is the common name for ammonium dodecyl sulfate. ALS is classified as an alkyl sulfate and is an anionic surfactant found primarily in shampoos and body-wash as a foaming agent. Lauryl sulfates are very high-foam surfactants that disrupt the surface tension of water by forming micelles around the polar water molecules. (L1891)
- FORMULA: C12H29NO4S
- DATA SOURCES: DATA SOURCES: ARTICLE 4 | T3DB | PubChem | EPA in USA | FDA Indirect Food Additives | EPA USA - Pesticide Inerts
- LAST UPDATE: 28/04/2018
Mostly focused on Health Implications of Long Term Exposure to this substance
- SYMPTOMS: In high concentrations ALS may cause severe irritation to eyes and skin. Inhalation and ingestion may also cause irritation. (L1891)
- POSSIBLE HEALTH CONSEQUENCES: In high concentrations ALS may cause severe irritation to eyes and skin. Inhalation and ingestion may also cause irritation. ALS may react to produce nitrosamines, which are believed to be carcinogenic. (L1890, L1891) | Nitrosamines can enter the body via ingestion, inhalation, or dermal contact. Once in the body, nitrosamines are metabolized by cytochrome P-450 enzymes, which essentially activates them into carcinogens. (A2878, A2879)
- ACTION OF TOXIN: While ammonium lauryl sulfate itself is not toxic, it is a nitrosating agent. Nitrosating agents may decompose and/or react to cause nitrosamine contamination. Nitrosamines are produced from secondary amines and amides in the presence of nitrite ions and are believed to be carcinogenic. Once in the body, nitrosamines are activated by cytochrome P-450 enzymes. They are then believed to induce their carcinogenic effects by forming DNA adducts at the N- and O-atoms. (L1889, L1890, A2878, A2879, A2880) | Ammonium lauryl sulfate is a nitrosating agent and may decompose and/or react to cause nitrosamine contamination. Nitrosamines are believed to induce carcinogenic effects by forming DNA adducts at the N- and O-atoms. (L1890, A2880)
- TOXIN SITES OF ACTION IN CELL: "Membrane"
- Additional Exposure Routes: Ammonium lauryl sulfate (ALS) is an anionic surfactant found primarily in shampoos and body-wash as a foaming agent. (L1891)
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