Toxno Substance Profile
Evidence-based data. We have more than 25,000 profiles on Toxno.
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Substance Name

Acetaldehyde
Identification Number: CASRN | 75-07-0

  Substance Attributes


  • Known Human Carcinogen

    This is a serious nasty substance. Exposure to this substance leads to cancer in Humans. Exercise extreme caution with this substance, explore your exposure routes and very seriously consider complete avoidance. See further details under Toxins.

  • Carcinogenic Properties

    Accumulating evidence points to cancer potential. Exercise caution with this substance, explore your exposure routes and consider complete avoidance. See further details under Toxins.

  • Metabolic Interference or Disruption

    Interferes with human metabolism. This can be a very serious thing. Some of these interference mechanics are well established. However, often long term effects and health consequences remain largely unknown. Additionally an emerging area of concern and one that is not currently studied, is the combined synergistic effects these metabolically disrupting chemicals have on human health.


    Metabolic interference happens when the substance produces highly reactive and often damaging intermediates during detoxification or when the substance binds to specific enzymes, important structural groups on molecules, receptors and membranes or targets DNA or mimics key nutrients.

  • Exposure Produces Health Symptoms

    Symptoms maybe short term or long term depending on the exposure duration and intensity and effects areas like Cardiovascular, Gastrointestinal, Cognition, Fatigue. A substance with this attribute may cause an allergic skin reaction, serious eye irritation, allergy or asthma symptoms or breathing difficulties if inhaled.

These attributes are ONLY based on peer-reviewed evidence. See link to Data Sources below. Everyone benefits from knowing this stuff. Please Share.



  • CATEGORIES: Chemical Found in Air near CSG Operations | Chemicals used in hydraulic fracturing fluids | Cigarette Toxin | Household Toxin | Industrial/Workplace Toxin | Pollutant | Airborne Pollutant | Food Toxin | Natural Toxin | Plant Toxin | Food Flavoring | EAFUS (Everything Added to Food in the United States) | Inert Pesticide Ingredient USA - FRAGRANCE ( Generally Not used on Food) | A Hazardous Substance that may be found in the Australian Workplace
  • SUBSTANCE LINEAGE: Organic Compounds | Organooxygen Compounds | Carbonyl Compounds | Aldehydes | Short-chain Aldehydes
  • SYNONYMS: Acetic aldehyde | Aldehyde | Ethanal | Ethyl aldehyde
  • DESCRIPTION: Has been used in CSG, Hydraulic Fracturing Operations (Fracking) as - Proppants - Manufactured | Acetaldehyde is a colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. In the chemical industry, acetaldehyde is used as an intermediate in the production of acetic acid, certain esters, and a number of other chemicals. it is also an air pollutant resulting from combustion, such as automotive exhaust and tobacco smoke. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis. Small amounts of acetaldehyde are produced naturally through gut microbial fermentation. Acetaldehyde is produced through the action of alcohol dehydrogenase on ethanol and is somewhate more toxic than ethanol. Acetaldehyde is linked to most of the negative clinical effects of alcohol. It has been shown to increase the risk of developing cirrhosis of the liver, multiple forms of cancer, and alcoholism.
  • COMMENTS: This Chemical is in the category of Carbonyls and is found in Air near CSG Operations

    From Safe Work Australia and the Hazardous Substances Information System (HSIS) in Australia:

    Extremely flammable liquid and vapour. Suspected of causing cancer. Causes serious eye irritation. May cause respiratory irritation | Chronic Health Hazard General Health Hazard | A Hazardous Substance that may be found in the Australian Workplace. Check with your employer or health and safety officer. Stay informed and become aware of the dangers that surround you. This chemical is included on the list of recognised hazardous chemicals from the Safe Work Australia - Hazardous Substances Information System (HSIS) that is based on the Globally Harmonised System of Classification and Labelling of Chemicals (GHS)

    Work Health and Safety (WHS) Regulations are the basis for hazardous chemicals regulations in Commonwealth, State and Territory jurisdictions in Australia. Under the model WHS Regulations, manufacturers and importers of substances, mixtures and articles supplied for use in workplaces are required to determine whether they are hazardous to health and safety before supply. The model WHS Regulations mandate that the hazards of a chemical as determined by the Globally Harmonised System of Classification and Labelling of Chemicals (GHS) must be included in safety data sheets and on labels. There are transitional arrangements in place for moving to the GHS-based system.

    The GHS Hazardous Chemical Information List contains chemicals classified by an authoritative source (such as the European Commission or NICNAS) in accordance with the Globally Harmonized System of Classification and Labelling of Chemicals (the GHS). This list contains the vast majority of chemicals currently in HSIS. This list and its detail are regularly updated by Work Safe Australia. The model Work Health and Safety (WHS) Regulations require chemicals to be classified in accordance with the Globally Harmonised System of Classification and Labelling of Chemicals (GHS). However transitional arrangements allow use of classification information in HSIS derived from the Approved Criteria until the 31 December 2016.
  • toxin chemical structure pubchem
  • FORMULA: C2H4O
  • DATA SOURCES: DATA SOURCES: ARTICLE 4 | CPDB | T3DB | PubChem | IARC | NTP | EPA_IRIS | OEHHA | FracFocus | EPA in USA | US HOUSE OF REPRESENTATIVES | Article-Colborn-Air | Flavornet | EAFUS | EPA USA - Pesticide Inerts | Safe Work Australia - Hazardous Substances Information System (HSIS)
  • LAST UPDATE: 28/04/2018

  Health Associations

Mostly focused on Health Implications of Long Term Exposure to this substance

  • SYMPTOMS: Skin contact with acetaldehyde causes irritation. (L1307)
  • POSSIBLE HEALTH CONSEQUENCES: Acetaldehyde is a probable carcinogen. (L1307) | In the liver, the enzyme acetaldehyde dehydrogenase converts acetaldehyde into the harmless compound acetic acid. (L1307)
  • ACTION OF TOXIN: Acetaldehyde can form adducts with DNA, causing damage such as cross-links. (A354) |
  • TOXIN SITES OF ACTION IN CELL: "Cytoplasm", "Endoplasmic reticulum", "Extracellular", "Mitochondria", "Peroxisome"
  • Additional Exposure Routes: Acetaldehyde occurs naturally in ripe fruit, coffee, and bread, and is produced by plants as part of their normal metabolism. It is popularly known as a chemical that causes hangovers, as it is produced from the breakdown of ethanol. In the chemical industry, acetaldehyde is used as an intermediate in the production of acetic acid, certain esters, and a number of other chemicals. it is also an air pollutant resulting from combustion, such as automotive exhaust and tobacco smoke. (L1307)

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  Exposure Routes

These are the Exposure Routes we have so far for this substance. There are almost certainly more. We update this section regularly. The number of chemicals with 2 or more nastiness attributes in an exposure route is shown in orange. They grey badge shows the total amount of chemicals within the exposure route.


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