Toxno Substance Profile
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Substance Name

Zinc oxide
Identification Number: CASRN | 1314-13-2

  Substance Attributes


  • Metabolic Interference or Disruption

    Interferes with human metabolism. This can be a very serious thing. Some of these interference mechanics are well established. However, often long term effects and health consequences remain largely unknown. Additionally an emerging area of concern and one that is not currently studied, is the combined synergistic effects these metabolically disrupting chemicals have on human health.


    Metabolic interference happens when the substance produces highly reactive and often damaging intermediates during detoxification or when the substance binds to specific enzymes, important structural groups on molecules, receptors and membranes or targets DNA or mimics key nutrients.

  • Exposure Produces Health Symptoms

    Symptoms maybe short term or long term depending on the exposure duration and intensity and effects areas like Cardiovascular, Gastrointestinal, Cognition, Fatigue. A substance with this attribute may cause an allergic skin reaction, serious eye irritation, allergy or asthma symptoms or breathing difficulties if inhaled.

  • Toxic to Wildlife

    May kill plants, fish, birds or other animals and insects or may be very toxic to aquatic life with long lasting effects. This then effects delicate environmental ecology and food supply in ways we don't fully understand yet.

These attributes are ONLY based on peer-reviewed evidence. See link to Data Sources below. Everyone benefits from knowing this stuff. Please Share.



  • CATEGORIES: Chemical used in hydraulic fracturing fluids | Household Toxin | Food Toxin | Synthetic Toxin | EAFUS (Everything Added to Food in the United States) | PESTICIDE active ingredient | Inert Pesticide Ingredient USA - Food Use Permitted | Pesticide approved in USA (California) | A Hazardous Substance that may be found in the Australian Workplace
  • SUBSTANCE LINEAGE: Inorganic Compounds | Mixed Metal/Non-metal Compounds | Transition Metal Organides | Transition Metal Oxides | Transition Metal Nitrites
  • SYNONYMS: Activox | Activox b | Actox 14 | Actox 16 | Actox 216 | Akro-zinc Bar 85 | Akro-zinc bar 90 | Amalox | Azo-55TT | Azo-66TT | Azo-77TT | Azodox | Azodox-55 | Azodox-55TT | Blanc de zinc | C-Weiss 8 | C.I. Pigment white 4 | Cadox XX 78 | Canfelzo | Chinese white | CI Pigment white 4 | Colloidal zinc oxide | Decelox | Dense zinc oxide | Denzox | Electox 2500 | Electrox | Electrox 2500 | Emanay zinc oxide | EMAR | Entrox | Extrox | Felling zinc oxide | Felzodox | Finex-25 | Flores de zinci | Flowers of zinc | Fotofax | Garozinc | GIAP 10 | Green seal-8 | Hubbuck'S white | Hubbucks white | K-Zinc | Kadox 15 | Kadox 72 | Kadox-25 | Ken-zinc | Leaded zinc oxide | Low purity zinc oxide | Methicone | Microx | No-genol | Nogenol | Octocure 553 | Outmine | Oxide | zinc | Ozide | OZLO | Paste | lassar's | Permanent white | Philosopher'S wool | Photozinc | Pigment white 4 | Powder base 900 | Protox 166 | Protox 168 | Protox 169 | Protox type 166 | Protox type 167 | Protox type 168 | Protox type 169 | Protox type 267 | Protox type 268 | Red Seal 9 | Rubox | Rvpaque | Snow white | Tertiary zinc oxide | Unichem zo | Vandem vac | Vandem voc | Vandem VPC | Vita zinc | White seal-7 | Zinc monoxide | Zinc oxides | Zinc white | Zinca 20 | Zinci oxicum | Zinci oxydum | Zincite | Zincoid | Zink white | Zinkoxid | Zinox | Ziradryl | ZnO
  • DESCRIPTION: Has been used in CSG, Hydraulic Fracturing Operations (Fracking) as - Unknown | Zinc oxide is a nutrient supplement. Zinc oxide is a constituent of cigarette filters for removal of selected components from tobacco smoke. Zinc oxide is a filter consisting of charcoal impregnated with zinc oxide and iron oxide removes significant amounts of HCN and H2S from tobacco smoke without affecting its flavor. Zinc oxide is an amphoteric oxide. It is nearly insoluble in water and alcohol, but it is soluble in (degraded by) most acids, such as hydrochloric acid:; Zinc oxide is an inorganic compound with the formula ZnO. It usually appears as a white powder, nearly insoluble in water. The powder is widely used as an additive into numerous materials and products including plastics, ceramics, glass, cement, rubber (e.g. car tyres), lubricants, paints, ointments, adhesives, sealants, pigments, foods (source of Zn nutrient), batteries, ferrites, fire retardants, first aid tapes, etc. ZnO is present in the Earth crust as a mineral zincite; however, most ZnO used commercially is produced synthetically. Zinc white is used as a pigment in paints and is more opaque than lithopone, but less opaque than titanium dioxide. It is also used in coatings for paper. Chinese white is a special grade of zinc white used in artists' pigments. Because it reflects both UVA and UVB rays of ultraviolet light, zinc oxide can be used in ointments, creams, and lotions to protect against sunburn and other damage to the skin caused by ultraviolet light (see sunscreen). It is the broadest spectrum UVA and UVB absorber that is approved for use as a sunscreen by the FDA, and is completely photostable. It is also a main ingredient of mineral makeup. ZnO is a relatively soft material with approximate hardness of 4.5 on the Mohs scale. Its elastic constants are smaller than those of relevant III-V semiconductors, such as GaN. The high heat capacity and heat conductivity, low thermal expansion and high melting temperature of ZnO are beneficial for ceramics.
    Zinc oxide has been shown to exhibit anti-inflammatory and antibiotic functions (A7764, A7765).
    Zinc oxide belongs to the family of Transition Metal Oxides. These are inorganic compounds containing an oxygen atom of an oxidation state of -2, in which the heaviest atom bonded to the oxygen is a transition metal.
  • COMMENTS:

    From Safe Work Australia and the Hazardous Substances Information System (HSIS) in Australia:

    Very toxic to aquatic life with long lasting effects | Environmental Hazard | A Hazardous Substance that may be found in the Australian Workplace. Check with your employer or health and safety officer. Stay informed and become aware of the dangers that surround you. This chemical is included on the list of recognised hazardous chemicals from the Safe Work Australia - Hazardous Substances Information System (HSIS) that is based on the Globally Harmonised System of Classification and Labelling of Chemicals (GHS)

    Work Health and Safety (WHS) Regulations are the basis for hazardous chemicals regulations in Commonwealth, State and Territory jurisdictions in Australia. Under the model WHS Regulations, manufacturers and importers of substances, mixtures and articles supplied for use in workplaces are required to determine whether they are hazardous to health and safety before supply. The model WHS Regulations mandate that the hazards of a chemical as determined by the Globally Harmonised System of Classification and Labelling of Chemicals (GHS) must be included in safety data sheets and on labels. There are transitional arrangements in place for moving to the GHS-based system.

    The GHS Hazardous Chemical Information List contains chemicals classified by an authoritative source (such as the European Commission or NICNAS) in accordance with the Globally Harmonized System of Classification and Labelling of Chemicals (the GHS). This list contains the vast majority of chemicals currently in HSIS. This list and its detail are regularly updated by Work Safe Australia. The model Work Health and Safety (WHS) Regulations require chemicals to be classified in accordance with the Globally Harmonised System of Classification and Labelling of Chemicals (GHS). However transitional arrangements allow use of classification information in HSIS derived from the Approved Criteria until the 31 December 2016.
  • toxin chemical structure pubchem
  • FORMULA: OZn
  • DATA SOURCES: DATA SOURCES: ARTICLE 4 | T3DB | PubChem | EPA in USA | US HOUSE OF REPRESENTATIVES | EAFUS | DPR | EPA USA - Pesticide Inerts | Safe Work Australia - Hazardous Substances Information System (HSIS)
  • LAST UPDATE: 28/04/2018

  Health Associations

Mostly focused on Health Implications of Long Term Exposure to this substance

  • SYMPTOMS: Ingestion of large doses of zinc causes stomach cramps, nausea, and vomiting. Acute inhalation of large amounts of zinc causes metal fume fever, which is characterized by chills, fever, headache, weakness, dryness of the nose and throat, chest pain, and coughing. Dermal contact with zinc results in skin irritation. (L49)
  • POSSIBLE HEALTH CONSEQUENCES: Chronic exposure to zinc causes anemia, atazia, lethargy, and decreases the level of good cholesterol in the body. It is also believed to cause pancreatic and reproductive damage. (L49) | Zinc can enter the body through the lungs, skin, and gastrointestinal tract. Intestinal absorption of zinc is controlled by zinc carrier protein CRIP. Zinc also binds to metallothioneins, which help prevent absorption of excess zinc. Zinc is widely distributed and found in all tissues and tissues fluids, concentrating in the liver, gastrointestinal tract, kidney, skin, lung, brain, heart, and pancreas. In the bloodstream zinc is found bound to carbonic anhydrase in erythrocytes, as well as bound to albumin, _2-macroglobulin, and amino acids in the the plasma. Albumin and amino acid bound zinc can diffuse across tissue membranes. Zinc is excreted in the urine and faeces. (L49)
  • ACTION OF TOXIN: Anaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unbalanced levels of copper and zinc binding to Cu,Zn-superoxide dismutase has been linked to amyotrophic lateral sclerosis (ALS). Stomach acid dissolves metallic zinc to give corrosive zinc chloride, which can cause damage to the stomach lining. Metal fume fever is thought to be an immune response to inhaled zinc. (L48, L49, A49) | Unbalanced levels of copper and zinc binding to Cu,Zn-superoxide dismutase has been linked to amyotrophic lateral sclerosis (ALS). (A49)
  • TOXIN SITES OF ACTION IN CELL: "Cytoplasm", "Extracellular"
  • Additional Exposure Routes: Zinc oxide is a semiconductor and used as an additive in materials such as plastics, ceramics, glass, cement, rubber, lubricants, paints, ointments, adhesives, sealants, dietary supplements, and batteries. (L72)

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