Toxno Substance Profile
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Substance Name

Zinc acetate
Identification Number: CASRN | 557-34-6

  Substance Attributes


  • Metabolic Interference or Disruption

    Interferes with human metabolism. This can be a very serious thing. Some of these interference mechanics are well established. However, often long term effects and health consequences remain largely unknown. Additionally an emerging area of concern and one that is not currently studied, is the combined synergistic effects these metabolically disrupting chemicals have on human health.


    Metabolic interference happens when the substance produces highly reactive and often damaging intermediates during detoxification or when the substance binds to specific enzymes, important structural groups on molecules, receptors and membranes or targets DNA or mimics key nutrients.

  • Exposure Produces Health Symptoms

    Symptoms maybe short term or long term depending on the exposure duration and intensity and effects areas like Cardiovascular, Gastrointestinal, Cognition, Fatigue. A substance with this attribute may cause an allergic skin reaction, serious eye irritation, allergy or asthma symptoms or breathing difficulties if inhaled.

  • Has known Side Effects

    This is often the result of long or short term medication use. The same medication can have a range of side effects ranging from none at all to totally debilitating symptoms within different individuals. Reasons for this include individual genetics, individual detoxification capacity, nutrition status, duration of use and total number of medications being taken.


    It becomes very difficult to establish clear causes of symptoms when multiple medications are being taken at once.


    See SIDE EFFECTS LINKOUT at end of this profile.

These attributes are ONLY based on peer-reviewed evidence. See link to Data Sources below. Everyone benefits from knowing this stuff. Please Share.



  • CATEGORIES: Food Additives with E Numbers | Acid, acidity regulators, anti-caking agents, anti-foaming agents, bulking agents, carriers and carrier solvents, emulsifying salts, firming agents, flavour enhancers, flour treatment agents, foaming agents, glazing agents, humectants, modified starches, packaging gases, propellants, raising agents and sequestrants. | Household Toxin | Industrial/Workplace Toxin | Food Toxin | Synthetic Toxin | EAFUS (Everything Added to Food in the United States) | Medication Approved in USA
  • SUBSTANCE LINEAGE: Organic Compounds | Organic Acids and Derivatives | Carboxylic Acids and Derivatives | Carboxylic Acid Derivatives | Acetate salts
  • SYNONYMS: Acetic acid | zinc salt | Acetic acid | zinc(II) salt | Dicarbomethoxyzinc | Zinc acetic acid | Zinc diacetate
  • DESCRIPTION: E Number: E650 | Food Additives with E Numbers used in Australia, NZ, UK and the EU. Over 400 in total. | Substance has been approved in: EU and UK | | Acid, acidity regulators, anti-caking agents, anti-foaming agents, bulking agents, carriers and carrier solvents, emulsifying salts, firming agents, flavour enhancers, flour treatment agents, foaming agents, glazing agents, humectants, modified starches, packaging gases, propellants, raising agents and sequestrants. | Nutrient supplement. Zinc acetate is the chemical compound with the formula Zn(O2CCH3)2, which commonly occurs as a dihydrate Zn(O2CCH3)2(H2O)2. Both the hydrate and the anhydrous forms are colorless solids that are commonly used in chemical synthesis and as dietary supplements. Zinc acetates are prepared by the action of acetic acid on zinc carbonate or zinc metal. When used as a food additive, it has the E number E650. (Wikipedia).
  • COMMENTS:
  • toxin chemical structure pubchem
  • FORMULA: C4H6O4Zn
  • DATA SOURCES: DATA SOURCES: ARTICLE 4 | T3DB | PubChem | FSANZ and FSA | EAFUS | USA FDA APPROVED DRUG PRODUCTS
  • LAST UPDATE: 28/04/2018

  Health Associations

Mostly focused on Health Implications of Long Term Exposure to this substance

  • SYMPTOMS: Ingestion of large doses of zinc causes stomach cramps, nausea, and vomiting. Acute inhalation of large amounts of zinc causes metal fume fever, which is characterized by chills, fever, headache, weakness, dryness of the nose and throat, chest pain, and coughing. Dermal contact with zinc results in skin irritation. (L49)
  • POSSIBLE HEALTH CONSEQUENCES: Chronic exposure to zinc causes anemia, atazia, lethargy, and decreases the level of good cholesterol in the body. It is also believed to cause pancreatic and reproductive damage. (L49) | Zinc can enter the body through the lungs, skin, and gastrointestinal tract. Intestinal absorption of zinc is controlled by zinc carrier protein CRIP. Zinc also binds to metallothioneins, which help prevent absorption of excess zinc. Zinc is widely distributed and found in all tissues and tissues fluids, concentrating in the liver, gastrointestinal tract, kidney, skin, lung, brain, heart, and pancreas. In the bloodstream zinc is found bound to carbonic anhydrase in erythrocytes, as well as bound to albumin, _2-macroglobulin, and amino acids in the the plasma. Albumin and amino acid bound zinc can diffuse across tissue membranes. Zinc is excreted in the urine and faeces. (L49)
  • ACTION OF TOXIN: Anaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unbalanced levels of copper and zinc binding to Cu,Zn-superoxide dismutase has been linked to amyotrophic lateral sclerosis (ALS). Stomach acid dissolves metallic zinc to give corrosive zinc chloride, which can cause damage to the stomach lining. Metal fume fever is thought to be an immune response to inhaled zinc. (L48, L49, A49) | Unbalanced levels of copper and zinc binding to Cu,Zn-superoxide dismutase has been linked to amyotrophic lateral sclerosis (ALS). (A49)
  • TOXIN SITES OF ACTION IN CELL: "Actin Filament", "Apical Membrane", "Cell junction", "Cell surface", "Cytoplasm", "Cytoskeleton", "Cytosol", "Early endosome", "Endoplasmic reticulum", "Endosome", "Extracellular", "Extracellular matrix", "Focal adhesion", "Golgi apparatus", "Intracellular Vesicle", "Microsome", "Microtubule", "Mitochondrion", "Nuclear Membrane", "Nucleolus", "Peroxisomal Matrix", "Peroxisomal Membrane", "Peroxisome", "Plasma Membrane", "Ribosome", "Sarcoplasm", "Sarcoplasmic Reticulum", "Synaptic Vesicle"
  • Additional Exposure Routes: Zinc acetate is used in dietary supplements, wood preserving, and the manufacturing other zinc salts and chemicals. (L61)
  • SEE MEDICATION SIDE EFFECTS

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  Exposure Routes

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