Toxno Substance Profile
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Substance Name

Zinc phenolsulfate
Identification Number: CASRN | 127-82-2

  Substance Attributes


  • Metabolic Interference or Disruption

    Interferes with human metabolism. This can be a very serious thing. Some of these interference mechanics are well established. However, often long term effects and health consequences remain largely unknown. Additionally an emerging area of concern and one that is not currently studied, is the combined synergistic effects these metabolically disrupting chemicals have on human health.


    Metabolic interference happens when the substance produces highly reactive and often damaging intermediates during detoxification or when the substance binds to specific enzymes, important structural groups on molecules, receptors and membranes or targets DNA or mimics key nutrients.

  • Exposure Produces Health Symptoms

    Symptoms maybe short term or long term depending on the exposure duration and intensity and effects areas like Cardiovascular, Gastrointestinal, Cognition, Fatigue. A substance with this attribute may cause an allergic skin reaction, serious eye irritation, allergy or asthma symptoms or breathing difficulties if inhaled.

These attributes are ONLY based on peer-reviewed evidence. See link to Data Sources below. Everyone benefits from knowing this stuff. Please Share.



  • CATEGORIES: Household Toxin | Industrial/Workplace Toxin | Synthetic Toxin
  • SUBSTANCE LINEAGE: Organic Compounds | Organic Acids and Derivatives | Sulfonic Acids and Derivatives | Arylsulfonic Acids and Derivatives | Benzenesulfonic Acid Derivatives
  • SYNONYMS: 1-Phenol-4-sulfonic acid zinc salt | 4-Hydroxybenzenesulfonic acid (2:1) | Benzenesulfonic acid | 4-hydroxy- | zinc salt (2:1) | Benzenesulfonic acid | P-hydroxy- | zinc salt (2:1) | Caswell No. 921A | P-Hydroxybenzenesulfonic acid zinc salt | Phenozin | Universal ZPS | Zinc 1-phenol-4-sulfonate(p) | Zinc bis(4-hydroxybenzenesulphonate) | Zinc p-hydroxybenzenesulfonate | Zinc p-phenol sulfonate | Zinc p-phenolsulfonate | Zinc phenol sulfonate | Zinc phenolsulfic acid | Zinc phenolsulfonate | Zinc sulfocarbolate | Zinc sulfophenate | Zinc-1,4-phenolsulfonate
  • DESCRIPTION: Zinc phenolsulfate is a chemical compound of zinc. Zinc is a metallic element with the atomic number 30. It is found in nature most often as the mineral sphalerite. Though excess zinc in harmful, in smaller amounts it is an essential element for life, as it is a cofactor for over 300 enzymes and is found in just as many transcription factors. (L48, L49)
  • COMMENTS:
  • toxin chemical structure pubchem
  • FORMULA: C12H10O8S2Zn
  • DATA SOURCES: DATA SOURCES: ARTICLE 4 | T3DB | PubChem
  • LAST UPDATE: 28/04/2018

  Health Associations

Mostly focused on Health Implications of Long Term Exposure to this substance

  • SYMPTOMS: Ingestion of large doses of zinc causes stomach cramps, nausea, and vomiting. Acute inhalation of large amounts of zinc causes metal fume fever, which is characterized by chills, fever, headache, weakness, dryness of the nose and throat, chest pain, and coughing. Dermal contact with zinc results in skin irritation. (L49)
  • POSSIBLE HEALTH CONSEQUENCES: Chronic exposure to zinc causes anemia, atazia, lethargy, and decreases the level of good cholesterol in the body. It is also believed to cause pancreatic and reproductive damage. (L49) | Zinc can enter the body through the lungs, skin, and gastrointestinal tract. Intestinal absorption of zinc is controlled by zinc carrier protein CRIP. Zinc also binds to metallothioneins, which help prevent absorption of excess zinc. Zinc is widely distributed and found in all tissues and tissues fluids, concentrating in the liver, gastrointestinal tract, kidney, skin, lung, brain, heart, and pancreas. In the bloodstream zinc is found bound to carbonic anhydrase in erythrocytes, as well as bound to albumin, _2-macroglobulin, and amino acids in the the plasma. Albumin and amino acid bound zinc can diffuse across tissue membranes. Zinc is excreted in the urine and faeces. (L49)
  • ACTION OF TOXIN: Anaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unbalanced levels of copper and zinc binding to Cu,Zn-superoxide dismutase has been linked to amyotrophic lateral sclerosis (ALS). Stomach acid dissolves metallic zinc to give corrosive zinc chloride, which can cause damage to the stomach lining. Metal fume fever is thought to be an immune response to inhaled zinc. (L48, L49, A49) | Unbalanced levels of copper and zinc binding to Cu,Zn-superoxide dismutase has been linked to amyotrophic lateral sclerosis (ALS). (A49)
  • TOXIN SITES OF ACTION IN CELL: "Cytoplasm", "Extracellular"
  • Additional Exposure Routes:

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  Exposure Routes

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