Toxno Substance Profile
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Substance Name

Ethenyl acetate
Identification Number: CASRN | 108-05-4

  Substance Attributes


  • Known Human Carcinogen

    This is a serious nasty substance. Exposure to this substance leads to cancer in Humans. Exercise extreme caution with this substance, explore your exposure routes and very seriously consider complete avoidance. See further details under Toxins.

  • Carcinogenic Properties

    Accumulating evidence points to cancer potential. Exercise caution with this substance, explore your exposure routes and consider complete avoidance. See further details under Toxins.

  • Metabolic Interference or Disruption

    Interferes with human metabolism. This can be a very serious thing. Some of these interference mechanics are well established. However, often long term effects and health consequences remain largely unknown. Additionally an emerging area of concern and one that is not currently studied, is the combined synergistic effects these metabolically disrupting chemicals have on human health.


    Metabolic interference happens when the substance produces highly reactive and often damaging intermediates during detoxification or when the substance binds to specific enzymes, important structural groups on molecules, receptors and membranes or targets DNA or mimics key nutrients.

  • Exposure Produces Health Symptoms

    Symptoms maybe short term or long term depending on the exposure duration and intensity and effects areas like Cardiovascular, Gastrointestinal, Cognition, Fatigue. A substance with this attribute may cause an allergic skin reaction, serious eye irritation, allergy or asthma symptoms or breathing difficulties if inhaled.

These attributes are ONLY based on peer-reviewed evidence. See link to Data Sources below. Everyone benefits from knowing this stuff. Please Share.



  • CATEGORIES: Cigarette Toxin | Household Toxin | Industrial/Workplace Toxin | Pollutant | Airborne Pollutant | Food Toxin | Synthetic Toxin | EAFUS (Everything Added to Food in the United States) | Inert Pesticide Ingredient USA - Non Food Use Only | A Hazardous Substance that may be found in the Australian Workplace
  • SUBSTANCE LINEAGE: Organic Compounds | Organic Acids and Derivatives | Carboxylic Acids and Derivatives | Carboxylic Acid Derivatives | Enol Esters
  • SYNONYMS: CH3CO2CH=CH2 | Ethenyl acetate | 9CI | Ethenyl acetic acid | Everflex 81L | Unocal 76 Res 6206 | Unocal 76 Res S-55 | VAC | Vinile | Vinnapas A 50 | Vinyl acetate | Vinyl ester of acetic acid | Vinyle
  • DESCRIPTION: Polyvinyl acetate is used as a food additive [EAFUS] (EAFUS: Everything Added to Food in the United States. [http://www.eafus.com/]). Ethenyl acetate belongs to the family of Carboxylic Acid Esters. These are carboxylic acid derivatives in which the carbo atom from the carbonyl group is atached to an alkyl or oaryl moiety through an oxygen atom (forming an ester group).
  • COMMENTS:

    From Safe Work Australia and the Hazardous Substances Information System (HSIS) in Australia:

    Highly flammable liquid and vapour | | A Hazardous Substance that may be found in the Australian Workplace. Check with your employer or health and safety officer. Stay informed and become aware of the dangers that surround you. This chemical is included on the list of recognised hazardous chemicals from the Safe Work Australia - Hazardous Substances Information System (HSIS) that is based on the Globally Harmonised System of Classification and Labelling of Chemicals (GHS)

    Work Health and Safety (WHS) Regulations are the basis for hazardous chemicals regulations in Commonwealth, State and Territory jurisdictions in Australia. Under the model WHS Regulations, manufacturers and importers of substances, mixtures and articles supplied for use in workplaces are required to determine whether they are hazardous to health and safety before supply. The model WHS Regulations mandate that the hazards of a chemical as determined by the Globally Harmonised System of Classification and Labelling of Chemicals (GHS) must be included in safety data sheets and on labels. There are transitional arrangements in place for moving to the GHS-based system.

    The GHS Hazardous Chemical Information List contains chemicals classified by an authoritative source (such as the European Commission or NICNAS) in accordance with the Globally Harmonized System of Classification and Labelling of Chemicals (the GHS). This list contains the vast majority of chemicals currently in HSIS. This list and its detail are regularly updated by Work Safe Australia. The model Work Health and Safety (WHS) Regulations require chemicals to be classified in accordance with the Globally Harmonised System of Classification and Labelling of Chemicals (GHS). However transitional arrangements allow use of classification information in HSIS derived from the Approved Criteria until the 31 December 2016.
  • toxin chemical structure pubchem
  • FORMULA: C4H6O2
  • DATA SOURCES: DATA SOURCES: ARTICLE 4 | CPDB | T3DB | PubChem | IARC | EAFUS | EPA USA - Pesticide Inerts | Safe Work Australia - Hazardous Substances Information System (HSIS)
  • LAST UPDATE: 28/04/2018

  Health Associations

Mostly focused on Health Implications of Long Term Exposure to this substance

  • SYMPTOMS: Inhalation of vinyl acetate irritates the eyes, nose, and throat. Skin contact causes irritation and blisters. (L1304)
  • POSSIBLE HEALTH CONSEQUENCES: Vinyl acetate may affect the immune system. It may also be a carcinogen. (L1304) | Vinyl acetate may be absorbed following ingestion, inhalation, or dermal exposure, and distributes throughout the body. It is rapidly hydrolyzed by esterases in the blood to acetate and the unstable intermediate, vinyl alcohol. Vinyl alcohol is then rapidly converted to acetaldehyde, which in turn is metabolized to acetate in the liver. This in turn is incorporated into the "2 carbon pool" of normal body metabolism and eventually forms carbon dioxide as the major breakdown product, which is expired. (L1304)
  • ACTION OF TOXIN: One of the metabolites of vinyl acetate, acetaldehyde, is a known animal carcinogen. Acetaldehyde can form adducts with DNA, causing damage such as cross-links. (L1304, A354) |
  • TOXIN SITES OF ACTION IN CELL: "Cytoplasm", "Extracellular"
  • Additional Exposure Routes: Vinyl acetate is used mainly for the production of other industrial chemicals, such as polyvinyl acetate, an important polymer for which it is the precursor. These chemicals are used mainly to make glues for the packaging and building industries. They are also used to make paints, textiles, and paper. Vinyl acetate is also used as a coating in plastic films for food packaging and as a modifier of food starch. (L1302, L1304)

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  Exposure Routes

These are the Exposure Routes we have so far for this substance. There are almost certainly more. We update this section regularly. The number of chemicals with 2 or more nastiness attributes in an exposure route is shown in orange. They grey badge shows the total amount of chemicals within the exposure route.


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