Metabolic Interference or Disruption
Interferes with human metabolism. This can be a very serious thing. Some of these interference mechanics are well established. However, often long term effects and health consequences remain largely unknown. Additionally an emerging area of concern and one that is not currently studied, is the combined synergistic effects these metabolically disrupting chemicals have on human health.
Metabolic interference happens when the substance produces highly reactive and often damaging intermediates during detoxification or when the substance binds to specific enzymes, important structural groups on molecules, receptors and membranes or targets DNA or mimics key nutrients.
Exposure Produces Health Symptoms
Symptoms maybe short term or long term depending on the exposure duration and intensity and effects areas like Cardiovascular, Gastrointestinal, Cognition, Fatigue. A substance with this attribute may cause an allergic skin reaction, serious eye irritation, allergy or asthma symptoms or breathing difficulties if inhaled.
These attributes are ONLY based on peer-reviewed evidence. See link to Data Sources below. Everyone benefits from knowing this stuff. Please Share.
- CATEGORIES: Household Toxin | Industrial/Workplace Toxin | Natural Toxin | Inert Pesticide Ingredient USA - Non Food Use Only
- SUBSTANCE LINEAGE: Inorganic Compounds | Mixed Metal/Non-metal Compounds | Post-transition Metal Organides | Post-transition Metal Oxides | Post-transition Metal Oxides
- SYNONYMS: Cassiterite | Flowers OF tin | Stannic anhydride | Stannic dioxide | Stannic oxide | Stannoxyl | Tin dioxide | Tin oxide | Tin peroxide | White tin oxide
- DESCRIPTION: Tin oxide is an inorganic compound of tin found naturally as the mineral cassiterite. It is used in the synthesis of other chemicals, as pigment in the manufacture of glasses, enamels, and ceramic glazes, and as a polishing powder. Tin is a chemical element with the symbol Sn and atomic number 50. It is a natural component of the earth's crust and is obtained chiefly from the mineral cassiterite, where it occurs as tin dioxide. (L307, L309, L317)
- FORMULA: O2Sn
- DATA SOURCES: DATA SOURCES: ARTICLE 4 | T3DB | PubChem | EPA USA - Pesticide Inerts
- LAST UPDATE: 28/04/2018
Mostly focused on Health Implications of Long Term Exposure to this substance
- SYMPTOMS: Inorganic or organic tin compounds placed on the skin or in the eyes can produce skin and eye irritation. (L308)
- POSSIBLE HEALTH CONSEQUENCES: Ingestion of large amounts of inorganic tin compounds can cause stomachache, anemia, and liver and kidney problems. (L307, L308) | Though tin metal is very poorly absorbed, tin compounds may be absorbed via oral, inhalation, or dermal routes, with organotin compounds being much more readily absorbed than inorganic tin compounds. Tin may enter the bloodstream and bind to hemoglobin, where it is distributed and accumulates mainly in the kidney, liver, lung, and bone. Tin and its metabolites are excreted mainly in the urine and feces. (L308)
- ACTION OF TOXIN: Inorganic and organic tin compounds are weak inhibitors of alcohol dehydrogenase. (A183) | Inorganic and organic tin compounds are weak inhibitors of alcohol dehydrogenase. (A183)
- TOXIN SITES OF ACTION IN CELL: "Cytoplasm", "Extracellular"
- Additional Exposure Routes: Tin oxide is used in the synthesis of other chemicals, as pigment in the manufacture of glasses, enamels, and ceramic glazes, and as a polishing powder. (L317)
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