Toxno Substance Profile
Evidence-based data. We have more than 25,000 profiles on Toxno.
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Substance Name

Identification Number: CASRN | 148-79-8

  Substance Attributes

  • Metabolic Interference or Disruption

    Interferes with human metabolism. This can be a very serious thing. Some of these interference mechanics are well established. However, often long term effects and health consequences remain largely unknown. Additionally an emerging area of concern and one that is not currently studied, is the combined synergistic effects these metabolically disrupting chemicals have on human health.

    Metabolic interference happens when the substance produces highly reactive and often damaging intermediates during detoxification or when the substance binds to specific enzymes, important structural groups on molecules, receptors and membranes or targets DNA or mimics key nutrients.

  • Toxic to Wildlife

    May kill plants, fish, birds or other animals and insects or may be very toxic to aquatic life with long lasting effects. This then effects delicate environmental ecology and food supply in ways we don't fully understand yet.

  • Has known Side Effects

    This is often the result of long or short term medication use. The same medication can have a range of side effects ranging from none at all to totally debilitating symptoms within different individuals. Reasons for this include individual genetics, individual detoxification capacity, nutrition status, duration of use and total number of medications being taken.

    It becomes very difficult to establish clear causes of symptoms when multiple medications are being taken at once.

    See SIDE EFFECTS LINKOUT at end of this profile.

These attributes are ONLY based on peer-reviewed evidence. See link to Data Sources below. Everyone benefits from knowing this stuff. Please Share.

  • CATEGORIES: Medication or Drug | Pesticide | Household Toxin | Food Toxin | Synthetic Toxin | PESTICIDE active ingredient | organic | fungicide | Pesticide or Plant Growth Regulator Approved in Australia | Pesticide approved in USA (California) | Pesticide approved or pending approval in EU | A Hazardous Substance that may be found in the Australian Workplace | VETERINARY DRUG for which Maximum Residue Limits (MRL) have been set by the Codex Alimentarius - International Food Standards
  • SUBSTANCE LINEAGE: Organic Compounds | Heterocyclic Compounds | Benzimidazoles | | Benzimidazoles
  • SYNONYMS: 1yvm | 2-(1,3-Thiazol-4-yl)-1H-benzimidazole | 2-(1,3-Thiazol-4-yl)benzimidazole | 2-(4'-Thiazolyl)benzimidazole | 2-(4-Thiazolyl)-1H-Benzimidazole | 2-(4-Thiazolyl)-Benzimidazole | 2-(4-Thiazolyl)benzimidazole | 2-(Thiazol-4-yl)benzimidazole | 2-Thiazol-4-yl-1H-benzoimidazole | 2-Thiazole-4-ylbenzimidazole | 2-[4-Thiazoly]benzimidazole | 4-(2-benzimidazolyl)thiazole | 5-(4-Thiazolyl)benzimidazole | Apl-luster | Arbotect | Biogard | Bioguard | Bovizole | Captan t | Chemviron TK 100 | Cropasal | Drawipas | E-z-Ex | Eprofil | Equivet TZ | Equizole | Equizole a | Helmindrax octelmin | Hokustar HP | Hymush | Lombristop | Mertec | Mertect | Mertect 160 | Mertect 340f | Mertect LSP | Metasol tk 10 | Metasol TK 100 | Metasol TK-100 | Mintesol | Mintezol | Mintezole | Minzolum | MK 360 | Mycozol | Nemacin | Nemapan | Omnizole | Ormogal | Pitrizet | Polival | RPH | Sanaizol 100 | Sistesan | Storite | Syntol M100 | TBDZ | TBZ | TBZ 6 | TBZ 60W | Tebuzate | Tecto | Tecto 10P | Tecto 40F | Tecto 60 | Tecto b | Tecto RPH | Testo | Thiaben | Thiabendazol | Thiabendazole(usan) | Thiabendazole | BAN | BSI | ISO | JMAF | USAN | Thiabendazolum | Thiabendole | Thiabenzazole | Thiabenzole | Thibendole | Thibenzol | Thibenzole | Thibenzole 200 | Thibenzole att | Thiprazole | Tiabenda | Tiabendazol | Tiabendazole | Tiabendazole | INN | Tiabendazolum | Tibimix 20 | TMG | Tobaz | Top form wormer | Tresaderm | Triasox | Tubazole
  • DESCRIPTION: Thiabendazole is a fungicide and parasiticide. It is used primarily to control mold, blight, and other fungally caused diseases in fruits (e.g. oranges) and vegetables; it is also used as a prophylactic treatment for Dutch elm disease. As an antiparasitic, it is able to control roundworms (such as those causing strongyloidiasis), hookworms, and other helminth species which attack wild animals, livestock and humans.
  • COMMENTS: Residues of this pesticide are tested for on Australian Foods | Pesticide approved in Australia

    From Safe Work Australia and the Hazardous Substances Information System (HSIS) in Australia:

    Very toxic to aquatic life with long lasting effects | Environmental Hazard | A Hazardous Substance that may be found in the Australian Workplace. Check with your employer or health and safety officer. Stay informed and become aware of the dangers that surround you. This chemical is included on the list of recognised hazardous chemicals from the Safe Work Australia - Hazardous Substances Information System (HSIS) that is based on the Globally Harmonised System of Classification and Labelling of Chemicals (GHS)

    Work Health and Safety (WHS) Regulations are the basis for hazardous chemicals regulations in Commonwealth, State and Territory jurisdictions in Australia. Under the model WHS Regulations, manufacturers and importers of substances, mixtures and articles supplied for use in workplaces are required to determine whether they are hazardous to health and safety before supply. The model WHS Regulations mandate that the hazards of a chemical as determined by the Globally Harmonised System of Classification and Labelling of Chemicals (GHS) must be included in safety data sheets and on labels. There are transitional arrangements in place for moving to the GHS-based system.

    The GHS Hazardous Chemical Information List contains chemicals classified by an authoritative source (such as the European Commission or NICNAS) in accordance with the Globally Harmonized System of Classification and Labelling of Chemicals (the GHS). This list contains the vast majority of chemicals currently in HSIS. This list and its detail are regularly updated by Work Safe Australia. The model Work Health and Safety (WHS) Regulations require chemicals to be classified in accordance with the Globally Harmonised System of Classification and Labelling of Chemicals (GHS). However transitional arrangements allow use of classification information in HSIS derived from the Approved Criteria until the 31 December 2016.
  • toxin chemical structure pubchem
  • DATA SOURCES: DATA SOURCES: ARTICLE 4 | T3DB | PubChem | Consolidated Pesticide Information Dataset (CPI) from the USA EPA | Compendium of Pesticide Common Names | APVMA | DPR | EU Pesticides | Safe Work Australia - Hazardous Substances Information System (HSIS) | Drugbank | USA FDA APPROVED DRUG PRODUCTS | Codex Alimentarius - International Food Standards - Veterinary Drugs
  • LAST UPDATE: 28/04/2018

  Health Associations

Mostly focused on Health Implications of Long Term Exposure to this substance

  • POSSIBLE HEALTH CONSEQUENCES: | Hepatic. Metabolized almost completely to the 5-hydroxy form which appears in the urine as glucuronide or sulfate conjugates. Route of Elimination: It is metabolized almost completely to the 5-hydroxy form which appears in the urine as glucuronide or sulfate conjugates. Half Life: The half-life for thiabendazole in both normal and anephric patients is 1.2 hours (range 0.9 to 2 hours). The half-life for the 5-hydroxythiabendazole metabolite in both normal and anephric patients is 1.7 hours (range 1.4 to 2 hours).
  • ACTION OF TOXIN: The precise mode of action of thiabendazole on the parasite is unknown, but it most likely inhibits the helminth-specific enzyme fumarate reductase. |
  • Additional Exposure Routes: For the treatment of strongyloidiasis (threadworm), cutaneous larva migrans (creeping eruption), visceral larva migrans, and trichinosis.

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  Exposure Routes

These are the Exposure Routes we have so far for this substance. There are almost certainly more. We update this section regularly. The number of chemicals with 2 or more nastiness attributes in an exposure route is shown in orange. They grey badge shows the total amount of chemicals within the exposure route.

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