Metabolic Interference or Disruption
Interferes with human metabolism. This can be a very serious thing. Some of these interference mechanics are well established. However, often long term effects and health consequences remain largely unknown. Additionally an emerging area of concern and one that is not currently studied, is the combined synergistic effects these metabolically disrupting chemicals have on human health.
Metabolic interference happens when the substance produces highly reactive and often damaging intermediates during detoxification or when the substance binds to specific enzymes, important structural groups on molecules, receptors and membranes or targets DNA or mimics key nutrients.
Exposure Produces Health Symptoms
Symptoms maybe short term or long term depending on the exposure duration and intensity and effects areas like Cardiovascular, Gastrointestinal, Cognition, Fatigue. A substance with this attribute may cause an allergic skin reaction, serious eye irritation, allergy or asthma symptoms or breathing difficulties if inhaled.
These attributes are ONLY based on peer-reviewed evidence. See link to Data Sources below. Everyone benefits from knowing this stuff. Please Share.
- CATEGORIES: Household Toxin | Natural Toxin | Indirect Additives Used in Food Contact Substances | Inert Pesticide Ingredient USA - Food Use Permitted
- SUBSTANCE LINEAGE: Organic Compounds | Organic Acids and Derivatives | Carboxylic Acids and Derivatives | Amino Acids, Peptides, and Analogues | N-acyl Amines
- SYNONYMS: (dodecanoyl(methyl)amino)acetic acid | Gardol | Hamposyl L-30 | Lauroylsarcosine sodium salt | Maprosyl 30 | Medialan LL-99 | N-dodecanoyl-n-methylglycine sodium salt | N-dodecanoyl-n-methylglycine | sodium salt | N-lauroylsarcosine sodium | N-lauroylsarcosine sodium salt | N-lauroylsarcosine sodium salt solution | N-Methyl-N-(1-oxododecyl)glycine sodium salt | Sarcosyl | Sarcosyl NL | Sarcosyl NL 30 | Sarkosyl NL | Sarkosyl NL 100 | Sarkosyl NL 30 | Sarkosyl NL 35 | Sarkosyl NL 97 | Sarkosyl NL-100 | Sarkosyl NL-30 | Sodium lauroyl sarcosinic acid | Sodium lauroylsarcosinate | Sodium lauroylsarcosine | Sodium n-dodecanoyl-n-methylglycinate | Sodium n-lauroylsarcosinate | Sodium n-lauroylsarcosinate solution | Sodium n-lauroylsarcosine | Sodium [dodecanoyl(methyl)amino]acetate
- DESCRIPTION: Sodium lauroyl sarcosinate is an sodium salt of an acyl derivative of sarcosine, which is a natural amino acid found in muscles and other body tissues. Acyl sarcosines are considered modified fatty acids in which the hydrocarbon chains are interrupted by an amidomethyl group in the alpha position. They are used as hair-conditioning agents and surfactant-cleansing agents in cosmetics, as well as to improve wetting and penetration of topical pharmaceutical products. Acyl sarcosines and their sodium salts are also used in the metal finishing and processing industries for their crystal modifying, anti-rust, and anti-corrosion properties. (L1892, A2881)
- FORMULA: C15H28NNaO3
- DATA SOURCES: DATA SOURCES: ARTICLE 4 | T3DB | PubChem | FDA Indirect Food Additives | EPA USA - Pesticide Inerts
- LAST UPDATE: 28/04/2018
Mostly focused on Health Implications of Long Term Exposure to this substance
- SYMPTOMS: Acyl sarcosines may cause irritation to the skin and eyes. (A2881)
- POSSIBLE HEALTH CONSEQUENCES: Acyl sarcosines may cause irritation to the skin and eyes. They may also react to produce N-nitrososarcosine, which is believed to be carcinogenic. (A2881) | Acyl sarcosines can be absorbed following oral or dermal contact, while nitrosamines can enter the body via ingestion, inhalation, or dermal contact. Once in the body, nitrosamines are metabolized by cytochrome P-450 enzymes, which essentially activates them into carcinogens. Sarcosine is metabolized to glycine by the enzyme sarcosine dehydrogenase. (A2878, A2879, L1892)
- ACTION OF TOXIN: While acyl sarcosines themselves are not toxic, they are nitrosating agents. Nitrosating agents may decompose and/or react to cause nitrosamine contamination. Nitrosamines are produced from secondary amines and amides in the presence of nitrite ions and are believed to be carcinogenic. The particular nitrosamine produced by acyl sarcosines is N-nitrososarcosine. Once in the body, nitrosamines are activated by cytochrome P-450 enzymes. They are then believed to induce their carcinogenic effects by forming DNA adducts at the N- and O-atoms. (L1889, L1890, A2878, A2879, A2880, A2881) | Acyl sarcosines are nitrosating agents and may decompose and/or react to cause nitrosamine contamination. The particular nitrosamine produced by acyl sarcosines is N-nitrososarcosine. Nitrosamines are believed to induce their carcinogenic effects by forming DNA adducts at the N- and O-atoms. (L1890, A2880, A2881)
- TOXIN SITES OF ACTION IN CELL: "Membrane"
- Additional Exposure Routes: Acyl sarcosines are used as hair-conditioning agents and surfactant-cleansing agents in cosmetics, as well as to improve wetting and penetration of topical pharmaceutical products. Acyl sarcosines and their sodium salts are also used in the metal finishing and processing industries for their crystal modifying, anti-rust, and anti-corrosion properties. (A2881)
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