Toxno Substance Profile
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Substance Name

Salicylic acid
Identification Number: CASRN | 69-72-7

  Substance Attributes


  • Metabolic Interference or Disruption

    Interferes with human metabolism. This can be a very serious thing. Some of these interference mechanics are well established. However, often long term effects and health consequences remain largely unknown. Additionally an emerging area of concern and one that is not currently studied, is the combined synergistic effects these metabolically disrupting chemicals have on human health.


    Metabolic interference happens when the substance produces highly reactive and often damaging intermediates during detoxification or when the substance binds to specific enzymes, important structural groups on molecules, receptors and membranes or targets DNA or mimics key nutrients.

  • Has known Side Effects

    This is often the result of long or short term medication use. The same medication can have a range of side effects ranging from none at all to totally debilitating symptoms within different individuals. Reasons for this include individual genetics, individual detoxification capacity, nutrition status, duration of use and total number of medications being taken.


    It becomes very difficult to establish clear causes of symptoms when multiple medications are being taken at once.


    See SIDE EFFECTS LINKOUT at end of this profile.

These attributes are ONLY based on peer-reviewed evidence. See link to Data Sources below. Everyone benefits from knowing this stuff. Please Share.



  • CATEGORIES: Medication or Drug | Household Toxin | Food Toxin | Natural Toxin | Synthetic Toxin | Plant Toxin | EAFUS (Everything Added to Food in the United States) | PESTICIDE active ingredient | Inert Pesticide Ingredient USA - Non Food Use Only | Pesticide approved in USA (California)
  • SUBSTANCE LINEAGE: Organic Compounds | Benzenoids | Benzene and Substituted Derivatives | Benzoic Acids and Derivatives | Salicylic Acids
  • SYNONYMS: 2-Carboxyphenol | 2-Hydroxybenzenecarboxylate | 2-Hydroxybenzenecarboxylic acid | 2-Hydroxybenzoate | 2-Hydroxybenzoic acid | Advanced Pain Relief Callus Removers | Advanced Pain Relief Corn Removers | Clear away Wart Remover | Compound W | Dr. Scholl'S Callus Removers | Dr. Scholl'S Corn Removers | Dr. Scholl'S Wart Remover Kit | Duofil Wart Remover | Duoplant | Freezone | Ionil | Ionil Plus | Ionil Plus shampoo | K 537 | K 557 | Keralyt | O-Carboxyphenol | O-Hydroxybenzoate | O-Hydroxybenzoic acid | Phenol-2-carboxylate | Phenol-2-carboxylic acid | Psoriacid-S-Stift | Retarder W | Rutranex | Salicylate | Salicylic acid collodion | Salicylic acid Soap | Saligel | Salonil | Stri-Dex | Stridex | Trans-Ver-Sal
  • DESCRIPTION: A compound obtained from the bark of the white willow and wintergreen leaves, and also prepared synthetically. It has bacteriostatic, fungicidal, and keratolytic actions. Its salts, the salicylates, are used as analgesics.
  • COMMENTS:
  • toxin chemical structure pubchem
  • FORMULA: C7H6O3
  • DATA SOURCES: DATA SOURCES: ARTICLE 4 | T3DB | PubChem | EAFUS | DPR | EPA USA - Pesticide Inerts | Drugbank | USA FDA APPROVED DRUG PRODUCTS
  • LAST UPDATE: 28/04/2018

  Health Associations

Mostly focused on Health Implications of Long Term Exposure to this substance

  • SYMPTOMS:
  • POSSIBLE HEALTH CONSEQUENCES: Investigated as a mutagen and reproductive effector. |
  • ACTION OF TOXIN: Salicylic acid directly and irreversibly inhibits the activity of both types of cyclo-oxygenases (COX-1 and COX-2) to decrease the formation of precursors of prostaglandins and thromboxanes from arachidonic acid. Salicylate may competitively inhibit prostaglandin formation. Salicylate's antirheumatic (nonsteroidal anti-inflammatory) actions are a result of its analgesic and anti-inflammatory mechanisms. Salicylic acid is a key ingredient in many skin-care products for the treatment of acne, psoriasis, calluses, corns, keratosis pilaris, and warts. It works by causing the cells of the epidermis to slough off more readily, preventing pores from clogging up, and allowing room for new cell growth. Because of its effect on skin cells, salicylic acid is used in several shampoos used to treat dandruff. Salicylic acid is also used as an active ingredient in gels which remove verrucas (plantar warts). Salicylic acid inhibits the oxidation of uridine-5-diphosphoglucose (UDPG) competitively with nicotinamide adenosine dinucleotide (NAD) and noncompetitively with UDPG. It also competitively inhibits the transferring of glucuronyl group of uridine-5-phosphoglucuronic acid (UDPGA) to the phenolic acceptor. The wound-healing retardation action of salicylates is probably due mainly to its inhibitory action on mucopolysaccharide synthesis. |
  • TOXIN SITES OF ACTION IN CELL: "Cytoplasm", "Extracellular"
  • Additional Exposure Routes: Key additive in many skin-care products for the treatment of acne, psoriasis, callouses, corns, keratosis pilaris and warts.
  • SEE MEDICATION SIDE EFFECTS

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  Exposure Routes

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