Toxno Substance Profile
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Substance Name

Riboflavin
Identification Number: CASRN | 83-88-5

  Substance Attributes


  • Metabolic Interference or Disruption

    Interferes with human metabolism. This can be a very serious thing. Some of these interference mechanics are well established. However, often long term effects and health consequences remain largely unknown. Additionally an emerging area of concern and one that is not currently studied, is the combined synergistic effects these metabolically disrupting chemicals have on human health.


    Metabolic interference happens when the substance produces highly reactive and often damaging intermediates during detoxification or when the substance binds to specific enzymes, important structural groups on molecules, receptors and membranes or targets DNA or mimics key nutrients.

  • Has known Side Effects

    This is often the result of long or short term medication use. The same medication can have a range of side effects ranging from none at all to totally debilitating symptoms within different individuals. Reasons for this include individual genetics, individual detoxification capacity, nutrition status, duration of use and total number of medications being taken.


    It becomes very difficult to establish clear causes of symptoms when multiple medications are being taken at once.


    See SIDE EFFECTS LINKOUT at end of this profile.

These attributes are ONLY based on peer-reviewed evidence. See link to Data Sources below. Everyone benefits from knowing this stuff. Please Share.



  • CATEGORIES: Food Additives with E Numbers | Colours | Medication or Drug | Food Toxin | Natural Toxin | Plant Toxin | EAFUS (Everything Added to Food in the United States) | Inert Pesticide Ingredient USA - Non Food Use Only
  • SUBSTANCE LINEAGE: Organic Compounds | Heterocyclic Compounds | Pteridines and Derivatives | Alloxazines and Isoalloxazines | Flavins
  • SYNONYMS: (-)-Riboflavin | 1-Deoxy-1-(3,4-dihydro-7,8-dimethyl-2,4-dioxobenzo[g]pteridin-10(2H)-yl)-D-ribitol | 1-Deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)pentitol | 6,7-Dimethyl-9-D-ribitylisoalloxazine | 6,7-Dimethyl-9-ribitylisoalloxazine | 7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)-Benzo[g]pteridine-2,4(3H,10H)-dione | 7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)benzo[g]pteridine-2,4(3H,10H)-dione | 7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)isoalloxazine | 7,8-Dimethyl-10-ribitylisoalloxazine | Beflavin | Beflavine | Benzo[g]pteridine riboflavin deriv. | Bisulase | E 101 | e101 | Flavaxin | Flavin BB | Flaxain | Food Yellow 15 | Hyre | Lactobene | Lactoflavin | Lactoflavine | Ribipca | Ribocrisina | Riboderm | Riboflavina | Riboflavine | Riboflavinum | Ribosyn | Ribotone | Ribovel | Russupteridine yellow III | San Yellow B | Vitaflavine | Vitamin B2 | Vitamin G | Vitasan B2
  • DESCRIPTION: E Number: E101 | Food Additives with E Numbers used in Australia, NZ, UK and the EU. Over 400 in total. | Substance has been approved in: Australia and NZ | EU and UK | | Colours | Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as flavin mononucleotide and flavin-adenine dinucleotide.
  • COMMENTS:
  • toxin chemical structure pubchem
  • FORMULA: C17H20N4O6
  • DATA SOURCES: DATA SOURCES: ARTICLE 4 | T3DB | PubChem | FSANZ and FSA | EAFUS | EPA USA - Pesticide Inerts | Drugbank
  • LAST UPDATE: 28/04/2018

  Health Associations

Mostly focused on Health Implications of Long Term Exposure to this substance

  • SYMPTOMS:
  • POSSIBLE HEALTH CONSEQUENCES: | Hepatic. Half Life: 66-84 minutes
  • ACTION OF TOXIN: Binds to riboflavin hydrogenase, riboflavin kinase, and riboflavin synthase. Riboflavin is the precursor of flavin mononucleotide (FMN, riboflavin monophosphate) and flavin adenine dinucleotide (FAD). The antioxidant activity of riboflavin is principally derived from its role as a precursor of FAD and the role of this cofactor in the production of the antioxidant reduced glutathione. Reduced glutathione is the cofactor of the selenium-containing glutathione peroxidases among other things. The glutathione peroxidases are major antioxidant enzymes. Reduced glutathione is generated by the FAD-containing enzyme glutathione reductase. |
  • TOXIN SITES OF ACTION IN CELL: "Cytoplasm", "Extracellular"
  • Additional Exposure Routes: For the treatment of ariboflavinosis (vitamin B2 deficiency).
  • SEE MEDICATION SIDE EFFECTS

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  Exposure Routes

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