Metabolic Interference or Disruption
Interferes with human metabolism. This can be a very serious thing. Some of these interference mechanics are well established. However, often long term effects and health consequences remain largely unknown. Additionally an emerging area of concern and one that is not currently studied, is the combined synergistic effects these metabolically disrupting chemicals have on human health.
Metabolic interference happens when the substance produces highly reactive and often damaging intermediates during detoxification or when the substance binds to specific enzymes, important structural groups on molecules, receptors and membranes or targets DNA or mimics key nutrients.
Exposure Produces Health Symptoms
Symptoms maybe short term or long term depending on the exposure duration and intensity and effects areas like Cardiovascular, Gastrointestinal, Cognition, Fatigue. A substance with this attribute may cause an allergic skin reaction, serious eye irritation, allergy or asthma symptoms or breathing difficulties if inhaled.
These attributes are ONLY based on peer-reviewed evidence. See link to Data Sources below. Everyone benefits from knowing this stuff. Please Share.
- CATEGORIES: Food Additives with E Numbers | Preservatives - nitrates and nitrites (also colour fixatives) | Household Toxin | Industrial/Workplace Toxin | Food Toxin | Synthetic Toxin | EAFUS (Everything Added to Food in the United States) | PESTICIDE active ingredient | Inert Pesticide Ingredient USA - Non Food Use Only | Pesticide approved in USA (California)
- SUBSTANCE LINEAGE: Inorganic Compounds | Mixed Metal/Non-metal Compounds | Alkali Metal Oxoanionic Compounds | Alkali Metal Nitrates | Alkali Metal Nitrites
- SYNONYMS: Collo-bo | Kali nitricum | KalII nitras | Kalium nitricum | Kaliumnitrat | Niter | Nitrate of potash | Nitre | Nitric acid potassium salt | Nitric acid potassium salt (1:1) | Nitric acid | potassium salt | Potassium nitrate(dot) | Potassium nitric acid | Salpetre | Salt peter | Saltpeter | Saltpetre | Sensodyne | Vicknite
- DESCRIPTION: E Number: E252 | Food Additives with E Numbers used in Australia, NZ, UK and the EU. Over 400 in total. | Substance has been approved in: Australia and NZ | EU and UK | | Can cause adverse reactions - best to avoid (Food Intolerance Network) | Preservatives - nitrates and nitrites (also colour fixatives) | Naturally occurring but more usually produced artificially from waste animal and vegetable material. This additive is one of the oldest and most effective preservatives for meat. Also acts as a curing agent. | Found in cured and cooked meats, and sausages. | Potassium nitrate is a nitrate of potassium. It is used as an oxidizing component of gunpowder, a preservative, a fertilizer, and can also be found in some toothpastes. Nitrite is a toxic compound known to cause methemoglobinemia. (L1137, L1634)
- FORMULA: KNO3
- DATA SOURCES: DATA SOURCES: ARTICLE 4 | T3DB | PubChem | FSANZ and FSA | EAFUS | DPR | EPA USA - Pesticide Inerts
- LAST UPDATE: 28/04/2018
Mostly focused on Health Implications of Long Term Exposure to this substance
- SYMPTOMS: Nitrate and nitrite poisoning causes methemoglobinemia. Symptoms include cyanosis, cardiac dysrhythmias and circulatory failure, and progressive central nervous system (CNS) effects. CNS effects can range from mild dizziness and lethargy to coma and convulsions. (L1137)
- POSSIBLE HEALTH CONSEQUENCES: Nitrate and nitrite poisoning causes methemoglobinemia. Nitrites may cause pregnancy complications and developmental effects. They may also be carcinogenic. (L1137) | Intake of some amount of nitrates and nitrites is a normal part of the nitrogen cycle in humans. In vivo conversion of nitrates to nitrites can occur in the gastrointestional tract under the right conditions, significantly enhancing nitrates' toxic potency. The major metabolic pathway for nitrate is conversion to nitrite, and then to ammonia. Nitrites, nitrates, and their metabolites are excreted in the urine. (L1137)
- ACTION OF TOXIN: Nitrate's toxicity is a result of it's conversion to nitrite once in the body. Nitrite causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and methemoglobin. This elevation of methemoglobin levels is a condition known as methemoglobinemia, and is characterized by tissue hypoxia, as methemoglobin cannot bind oxygen. (A2450, L1613) | Nitrite causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and methemoglobin. This elevation of methemoglobin levels is a condition known as methemoglobinemia, and is characterized by tissue hypoxia, as methemoglobin cannot bind oxygen. (A2450, L1613)
- TOXIN SITES OF ACTION IN CELL: "Cytoplasm", "Extracellular"
- Additional Exposure Routes:
Search all of Toxno
Or browse our mind blowing but terrifying Lists