Accumulating evidence points to cancer potential. Exercise caution with this substance, explore your exposure routes and consider complete avoidance. See further details under Toxins.
Metabolic Interference or Disruption
Interferes with human metabolism. This can be a very serious thing. Some of these interference mechanics are well established. However, often long term effects and health consequences remain largely unknown. Additionally an emerging area of concern and one that is not currently studied, is the combined synergistic effects these metabolically disrupting chemicals have on human health.
Metabolic interference happens when the substance produces highly reactive and often damaging intermediates during detoxification or when the substance binds to specific enzymes, important structural groups on molecules, receptors and membranes or targets DNA or mimics key nutrients.
Exposure Produces Health Symptoms
Symptoms maybe short term or long term depending on the exposure duration and intensity and effects areas like Cardiovascular, Gastrointestinal, Cognition, Fatigue. A substance with this attribute may cause an allergic skin reaction, serious eye irritation, allergy or asthma symptoms or breathing difficulties if inhaled.
These attributes are ONLY based on peer-reviewed evidence. See link to Data Sources below. Everyone benefits from knowing this stuff. Please Share.
- CATEGORIES: Chemical used in hydraulic fracturing fluids | Household Toxin | Industrial/Workplace Toxin | Food Toxin | Synthetic Toxin | EAFUS (Everything Added to Food in the United States) | Inert Pesticide Ingredient USA - Food Use Permitted
- SUBSTANCE LINEAGE: Organic Compounds | Organic Acids and Derivatives | Carboxylic Acids and Derivatives | Carboxylic Acid Derivatives | Carboxylic Acid Esters
- SYNONYMS: 1-acetoxyethylene | Acetate de vinyle | Acetic acid ethenyl ester | Acetic acid ethylene ether | Acetic acid vinyl ester | Acetoxyethene | Acetoxyethylene | Essigsaeurevinylester | Ethanoic acid | ethenyl ester | Ethenyl ethanoate | Octan winylu | Polyvinyl acetic acid | Vinile (acetato di) | Vinyl a monomer | Vinyl ethanoate | Vinylester kyseliny octove | VYAC | Zeset t
- DESCRIPTION: Has been used in CSG, Hydraulic Fracturing Operations (Fracking) as - Unknown | Polyvinyl acetate is a rubbery synthetic polymer. It is a component of glue and is used mainly as an adhesive for porous materials, particularly for wood, paper, and cloth. While polyvinyl acetate itself is not considered hazardous, it usually contains trace amounts of its precursor, vinyl acetate, which is toxic. (L1301, L1302)
- FORMULA: C6H12O2
- DATA SOURCES: DATA SOURCES: ARTICLE 4 | T3DB | PubChem | IARC | EPA in USA | EAFUS | EPA USA - Pesticide Inerts
- LAST UPDATE: 28/04/2018
Mostly focused on Health Implications of Long Term Exposure to this substance
- SYMPTOMS: Inhalation of vinyl acetate irritates the eyes, nose, and throat. Skin contact causes irritation and blisters. (L1304)
- POSSIBLE HEALTH CONSEQUENCES: Vinyl acetate may affect the immune system. It may also be a carcinogen. (L1304) | Vinyl acetate may be absorbed following ingestion, inhalation, or dermal exposure, and distributes throughout the body. It is rapidly hydrolyzed by esterases in the blood to acetate and the unstable intermediate, vinyl alcohol. Vinyl alcohol is then rapidly converted to acetaldehyde, which in turn is metabolized to acetate in the liver. This in turn is incorporated into the "2 carbon pool" of normal body metabolism and eventually forms carbon dioxide as the major breakdown product, which is expired. (L1304)
- ACTION OF TOXIN: Polyvinyl acetate usually contains trace amounts of its precursor, vinyl acetate. One of the metabolites of vinyl acetate, acetaldehyde, is a known animal carcinogen. Acetaldehyde can form adducts with DNA, causing damage such as cross-links. (L1304, A354) |
- TOXIN SITES OF ACTION IN CELL: "Actin Filament", "Apical Membrane", "Basolateral Membrane", "Cell junction", "Cell surface", "Cytoplasm", "Cytoskeleton", "Cytosol", "Endocytic Vesicle", "Endosome", "Extracellular", "Extracellular matrix", "Golgi apparatus", "Intermediate Filament", "Lysosome", "Membrane Fraction", "Microtubule", "Mitochondrion", "Nuclear Membrane", "Nucleoplasm", "Peroxisome", "Plasma Membrane", "Ribosome", "Sarcoplasmic Reticulum", "Soluble Fraction", "Synaptic Vesicle"
- Additional Exposure Routes: Polyvinyl acetate is a component of glue and is used mainly as an adhesive for porous materials, particularly for wood, paper, and cloth. (L1301)
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