Toxno Substance Profile
Evidence-based data. We have more than 25,000 profiles on Toxno.
Use Search below to seek out more. Or browse the Exposure Routes; alternatively see our Lists that have more substances than notes in a Liszt virtuoso piano piece.
Substance Name

Sodium laureth sulfate
Identification Number: CASRN | 9004-82-4

  Substance Attributes


  • Metabolic Interference or Disruption

    Interferes with human metabolism. This can be a very serious thing. Some of these interference mechanics are well established. However, often long term effects and health consequences remain largely unknown. Additionally an emerging area of concern and one that is not currently studied, is the combined synergistic effects these metabolically disrupting chemicals have on human health.


    Metabolic interference happens when the substance produces highly reactive and often damaging intermediates during detoxification or when the substance binds to specific enzymes, important structural groups on molecules, receptors and membranes or targets DNA or mimics key nutrients.

  • Exposure Produces Health Symptoms

    Symptoms maybe short term or long term depending on the exposure duration and intensity and effects areas like Cardiovascular, Gastrointestinal, Cognition, Fatigue. A substance with this attribute may cause an allergic skin reaction, serious eye irritation, allergy or asthma symptoms or breathing difficulties if inhaled.

These attributes are ONLY based on peer-reviewed evidence. See link to Data Sources below. Everyone benefits from knowing this stuff. Please Share.



  • CATEGORIES: Household Toxin | Synthetic Toxin | Inert Pesticide Ingredient USA - Food Use Permitted
  • SUBSTANCE LINEAGE: Organic Compounds | Organic Acids and Derivatives | Organic Sulfuric Acids and Derivatives | Sulfuric Acid Esters | Sulfuric Acid Monoesters
  • SYNONYMS: 2-(Dodecyloxy)ethanol hydrogen sulfate sodium salt | 2-(Dodecyloxy)ethyl sodium sulfate | Avirol 100E | Conco sulfate we | Cycloryl na | Dodecyl sodium ethoxysulfate | Elfan 242 | Elfan NS 242 | Elfan NS 243 | Empicol ESB 3 | Empicol ESB 30 | Empimin KSN | Empimin KSN 27 | Empimin KSN 60 | Empimin KSN 70 | Etoxon epa | Laureth-8 carboxylic acid sodium salt | Maprofix 60S | Maprofix es | PEG-12 Lauryl ether sulfate sodium salt | PEG-5 Lauryl ether sulfate sodium salt | PEG-7 Lauryl ether sulfate sodium salt | PEG-8 Lauryl ether sulfate sodium salt | Polyethylene glycol (5) lauryl ether sulfate sodium salt | Polyethylene Glycol (7) Lauryl Ether Sulfate Sodium Salt | Polyethylene glycol 400 lauryl ether sulfate sodium salt | Polyethylene glycol 600 lauryl ether sulfate sodium salt | Polyethylene glycol sulfate monododecyl ether sodium salt | Polyoxyethylene (12) lauryl ether sulfate sodium salt | Polyoxyethylene (5) lauryl ether sulfate sodium salt | Polyoxyethylene (7) lauryl ether sulfate sodium salt | Polyoxyethylene (8) lauryl ether sulfate sodium salt | Retzolate 60 | Rewopol NL-2 | Rhodapex esy | Sipon es | Sipon esy | Sipon LES 25 | Sodium (lauryloxypolyethoxy)ethyl sulfate | Sodium 2-(dodecyloxy)ethyl sulfate | Sodium 2-(dodecyloxy)ethyl sulphate | Sodium 2-(lauryloxy)ethyl sulfate | Sodium dodeceth-1 sulfate | Sodium dodecylpoly(oxyethylene) sulfate | Sodium laureth sulfic acid | Sodium laureth sulphate | Sodium laureth sulphic acid | Sodium laureth-12 sulfate | Sodium laureth-3 sulfate | Sodium laureth-5 sulfate | Sodium laureth-7 sulfate | Sodium laureth-8 sulfate | Sodium lauryl ether sulfate | Sodium lauryl ethoxysulphate | Sodium lauryl oxyethyl sulfate | Sodium lauryl sulfate ethoxylate | Sodium laurylpoly(oxyethylene) sulfate | Sodium poly(oxyethylene) lauryl ether sulfate | Sodium polyethylene glycol (5) lauryl ether sulfate | Sodium polyethylene glycol (7) lauryl ether sulfate | Sodium polyethylene glycol 400 sulfate | Sodium polyethylene glycol 600 lauryl ether sulfate | Sodium polyoxyethylene (12) lauryl ether sulfate | Sodium polyoxyethylene (5) lauryl ether sulfate | Sodium polyoxyethylene (7) lauryl ether sulfate | Sodium polyoxyethylene (8) sulfate | Standapol ES 2 | Standapol ES-3 | Steol CS-460 | Texapon N40 | Zetesol LES 2
  • DESCRIPTION: Sodium laureth sulfate is a detergent and surfactant found in many personal care products (soaps, shampoos, toothpaste etc.). It is an inexpensive and very effective foaming agent made by mixing sulfuric acid, monododecyl ester, and sodium salt. Sodium laureth sulfate may cause eye or skin irritation. (L1899)
  • COMMENTS:
  • toxin chemical structure pubchem
  • FORMULA: C14H29NaO5S
  • DATA SOURCES: DATA SOURCES: ARTICLE 4 | T3DB | PubChem | EPA USA - Pesticide Inerts
  • LAST UPDATE: 28/04/2018

  Health Associations

Mostly focused on Health Implications of Long Term Exposure to this substance

  • SYMPTOMS: Sodium laureth sulfate may cause skin and eye irritation, as well as increase the frequency of canker sores when used in toothpaste. (L1899)
  • POSSIBLE HEALTH CONSEQUENCES: Sodium laureth sulfate may cause skin and eye irritation, as well as increase the frequency of canker sores when used in toothpaste. It may also react to produce nitrosamines or contain low levels of 1,4-dioxane, both of which are believed to be carcinogenic. (L1890, L1899) | Nitrosamines can enter the body via ingestion, inhalation, or dermal contact. Once in the body, nitrosamines are metabolized by cytochrome P-450 enzymes, which essentially activates them into carcinogens. (A2878, A2879)
  • ACTION OF TOXIN: While sodium laureth sulfate itself is not toxic, it is a nitrosating agent. Nitrosating agents may decompose and/or react to cause nitrosamine contamination. Nitrosamines are produced from secondary amines and amides in the presence of nitrite ions and are believed to be carcinogenic. Once in the body, nitrosamines are activated by cytochrome P-450 enzymes. They are then believed to induce their carcinogenic effects by forming DNA adducts at the N- and O-atoms. Sodium laureth sulfate may also be contaminated with low levels of 1,4-dioxane, another believed carcinogen. (L1889, L1890, A2878, A2879, A2880, L1899) | Sodium laureth sulfate is a nitrosating agent and may decompose and/or react to cause nitrosamine contamination. Nitrosamines are believed to induce carcinogenic effects by forming DNA adducts at the N- and O-atoms. (L1890, A2880)
  • TOXIN SITES OF ACTION IN CELL: "Membrane"
  • Additional Exposure Routes: Sodium laureth sulfate is a detergent and surfactant found in many personal care products (soaps, shampoos, toothpaste etc.). (L1899)

 Search all of Toxno

Or browse our mind blowing but terrifying Lists.

  Exposure Routes

These are the Exposure Routes we have so far for this substance. There are almost certainly more. We update this section regularly. The number of chemicals with 2 or more nastiness attributes in an exposure route is shown in orange. They grey badge shows the total amount of chemicals within the exposure route.


  Stay Informed

Chemicals released in consumer products and the environment are constantly changing. Regulations change. Exposure Routes change. People speak up and nasties are removed while often others are introduced.

By signing up you will periodically receive updates of potentially life changing information. Both for yourself and your family.

We take security and privacy very seriously and you can unsubscribe at any time.


cats at toxno

"Yeh. We were surprised too"