Toxno Substance Profile
Evidence-based data. We have more than 25,000 profiles on Toxno.
Use Search below to seek out more. Or browse the Exposure Routes; alternatively see our Lists that have more substances than notes in a Liszt virtuoso piano piece.
Substance Name

Methanol
Identification Number: CASRN | 67-56-1

  Substance Attributes


  • Endocrine Disrupter

    Interferes with your hormones. Hormones are powerful messengers that can bind to DNA. You don't want to mess with them.

  • Mutagenic Properties

    Cause mutations to Genetic material like DNA, RNA or mitochondrial DNA

  • Reproductive Effects

    Interferes with fertility

  • Birth/Developmental

    Known to effect development of fetus.

  • Metabolic Interference or Disruption

    Interferes with human metabolism. This can be a very serious thing. Some of these interference mechanics are well established. However, often long term effects and health consequences remain largely unknown. Additionally an emerging area of concern and one that is not currently studied, is the combined synergistic effects these metabolically disrupting chemicals have on human health.


    Metabolic interference happens when the substance produces highly reactive and often damaging intermediates during detoxification or when the substance binds to specific enzymes, important structural groups on molecules, receptors and membranes or targets DNA or mimics key nutrients.

  • Exposure Produces Health Symptoms

    Symptoms maybe short term or long term depending on the exposure duration and intensity and effects areas like Cardiovascular, Gastrointestinal, Cognition, Fatigue. A substance with this attribute may cause an allergic skin reaction, serious eye irritation, allergy or asthma symptoms or breathing difficulties if inhaled.

  • Serious Acute Effects

    This is a serious nasty substance. Effects are Acute (seen immediately). Substances in this category may be FATAL or acutely toxic if inhaled, skin contact or swallowed. See further details.

  • Toxic to specific organs

    Can damage liver, kidney, lungs, heart or gut. Ironically liver, kidneys and gut are the main detoxifications systems.

  • Soluble in Water

    This substance easily dissolves in water. As such it can be easily transported via waterways. Not really a nastiness attribute, but this feature helps rapidly spread other nastiness attributes this substance may have.

  • Volatile - Evaporates easily

    This substance easily enters the air we breath. Not really a nastiness attribute, but this feature helps rapidly spread other nastiness attributes this substance may have.

These attributes are ONLY based on peer-reviewed evidence. See link to Data Sources below. Everyone benefits from knowing this stuff. Please Share.



  • CATEGORIES: Chemical Found in Air near CSG Operations | Chemicals used in hydraulic fracturing fluids | Chemicals detected in flowback and produced water - collectively referred to as - hydraulic fracturing wastewater | Household Toxin | Industrial/Workplace Toxin | Pollutant | Airborne Pollutant | Food Toxin | Natural Toxin | EAFUS (Everything Added to Food in the United States) | Inert Pesticide Ingredient USA - Non Food Use Only | Inert Pesticide Ingredient USA - FRAGRANCE ( Generally Not used on Food) | A Hazardous Substance that may be found in the Australian Workplace
  • SUBSTANCE LINEAGE: Organic Compounds | Organooxygen Compounds | Alcohols and Polyols | Primary Alcohols | Primary Alcohols
  • SYNONYMS: Carbinol | CH3OH | Colonial spirit | Columbian spirit | Columbian spirits | Hydroxymethane | Methyl alcohol | Methyl hydroxide | Methylol | Monohydroxymethane | Pyro alcohol | Pyroxylic spirit | Spirit of wood | Wood alcohol | Wood naphtha | Wood spirit
  • DESCRIPTION: Has been used in CSG, Hydraulic Fracturing Operations (Fracking) as - Biocide, defoamer, foamer, lubricant, crosslinker, pH balance, surfactant, non-emulsifier, emulsifier, corrosion inhibitor, antifreeze, surface tension, solvent, fracturing, unknown, scale inhibitor, hydrogen sulfide scavanger, clay stabilizer, breaker, surfactant, paraffin inhibitor | Methanol is the simplest alcohol, and is a light, volatile, colourless, flammable, poisonous liquid with a distinctive odor that is somewhat milder and sweeter than ethanol (Wikipedia). Methanol is responsible for accidental, suicidal, and epidemic poisonings, resulting in death or permanent sequelae. Toxicity is due to the metabolic products of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase. (A7768). The rapid and accurate diagnosis of toxic alcohol poisoning due to methanol (methyl alcohol) is paramount in preventing serious adverse outcomes. The quantitative measurement of specific serum levels of methanol using gas chromatography is expensive, time consuming and generally only available at major tertiary-care facilities. (A7769).
  • COMMENTS: This Chemical is in the category of VOC and is found in Air near CSG Operations

    From Safe Work Australia and the Hazardous Substances Information System (HSIS) in Australia:

    Highly flammable liquid and vapour. Toxic if inhaled. Toxic in contact with skin. Toxic if swallowed. Causes damage to organs | Chronic Health Hazard Acutely Toxic | A Hazardous Substance that may be found in the Australian Workplace. Check with your employer or health and safety officer. Stay informed and become aware of the dangers that surround you. This chemical is included on the list of recognised hazardous chemicals from the Safe Work Australia - Hazardous Substances Information System (HSIS) that is based on the Globally Harmonised System of Classification and Labelling of Chemicals (GHS)

    Work Health and Safety (WHS) Regulations are the basis for hazardous chemicals regulations in Commonwealth, State and Territory jurisdictions in Australia. Under the model WHS Regulations, manufacturers and importers of substances, mixtures and articles supplied for use in workplaces are required to determine whether they are hazardous to health and safety before supply. The model WHS Regulations mandate that the hazards of a chemical as determined by the Globally Harmonised System of Classification and Labelling of Chemicals (GHS) must be included in safety data sheets and on labels. There are transitional arrangements in place for moving to the GHS-based system.

    The GHS Hazardous Chemical Information List contains chemicals classified by an authoritative source (such as the European Commission or NICNAS) in accordance with the Globally Harmonized System of Classification and Labelling of Chemicals (the GHS). This list contains the vast majority of chemicals currently in HSIS. This list and its detail are regularly updated by Work Safe Australia. The model Work Health and Safety (WHS) Regulations require chemicals to be classified in accordance with the Globally Harmonised System of Classification and Labelling of Chemicals (GHS). However transitional arrangements allow use of classification information in HSIS derived from the Approved Criteria until the 31 December 2016.
  • toxin chemical structure pubchem
  • FORMULA: CH4O
  • DATA SOURCES: DATA SOURCES: ARTICLE 4 | T3DB | PubChem | OEHHA | Article-Colborn-2010 | FracFocus | EPA in USA | US HOUSE OF REPRESENTATIVES | Article-Colborn-Air | EAFUS | EPA USA - Pesticide Inerts | Safe Work Australia - Hazardous Substances Information System (HSIS)
  • LAST UPDATE: 28/04/2018

  Health Associations

Mostly focused on Health Implications of Long Term Exposure to this substance

  • SYMPTOMS: Methanol can produce sensory irritation and narcosis at airborne concentrations below those which produce organ system pathology. (T10)
  • POSSIBLE HEALTH CONSEQUENCES: Acute methanol poisoning in humans is characterized by an asymptomatic period of 12h to 24h followed by formic acidemia, ocular toxicity, coma, and in extreme cases death. Visual disturbances develop between 18h to 48h after ingestion and range from mild photophobia and blurred vision to markedly reduced visual acuity and complete blindness. (T10) | Methanol is metabolized to formaldehyde by alcohol dehydrogenase, then from that to formate by formaldehyde dehydrogenase, and then to carbon dioxide by limited H4 folate. (T10)
  • ACTION OF TOXIN: The target of methanol in the eye is the retina, specifically the optic disk and optic nerve. Muller cells and rod and cone cells are altered functionally and structurally, because cytochrome oxidase activity in mitochondria is inhibited, resulting in a reduction in ATP. (T10) | The toxic metabolite of Methanol that responsible for the retinal and optic nerve toxicity produced in methanol intoxication is Formic acid. Formic acid is a mitochondrial toxin that inhibits cytochrome c oxidase, the terminal enzyme of the mitochondrial electron transport chain of all eukaryotes. (A131)
  • TOXIN SITES OF ACTION IN CELL: "Cytoplasm", "Endoplasmic reticulum", "Extracellular", "Lysosome"
  • Additional Exposure Routes: Methanol is found in a host of consumer products, including windshield washer fluid, and is used in the manufacture of formaldehyde. (T10)

 Search all of Toxno

Or browse our mind blowing but terrifying Lists.

  Exposure Routes

These are the Exposure Routes we have so far for this substance. There are almost certainly more. We update this section regularly. The number of chemicals with 2 or more nastiness attributes in an exposure route is shown in orange. They grey badge shows the total amount of chemicals within the exposure route.


  Stay Informed

Chemicals released in consumer products and the environment are constantly changing. Regulations change. Exposure Routes change. People speak up and nasties are removed while often others are introduced.

By signing up you will periodically receive updates of potentially life changing information. Both for yourself and your family.

We take security and privacy very seriously and you can unsubscribe at any time.


cats at toxno

"Yeh. We were surprised too"