Metabolic Interference or Disruption
Interferes with human metabolism. This can be a very serious thing. Some of these interference mechanics are well established. However, often long term effects and health consequences remain largely unknown. Additionally an emerging area of concern and one that is not currently studied, is the combined synergistic effects these metabolically disrupting chemicals have on human health.
Metabolic interference happens when the substance produces highly reactive and often damaging intermediates during detoxification or when the substance binds to specific enzymes, important structural groups on molecules, receptors and membranes or targets DNA or mimics key nutrients.
Exposure Produces Health Symptoms
Symptoms maybe short term or long term depending on the exposure duration and intensity and effects areas like Cardiovascular, Gastrointestinal, Cognition, Fatigue. A substance with this attribute may cause an allergic skin reaction, serious eye irritation, allergy or asthma symptoms or breathing difficulties if inhaled.
Toxic to specific organs
Can damage liver, kidney, lungs, heart or gut. Ironically liver, kidneys and gut are the main detoxifications systems.
Soluble in Water
This substance easily dissolves in water. As such it can be easily transported via waterways. Not really a nastiness attribute, but this feature helps rapidly spread other nastiness attributes this substance may have.
Volatile - Evaporates easily
This substance easily enters the air we breath. Not really a nastiness attribute, but this feature helps rapidly spread other nastiness attributes this substance may have.
These attributes are ONLY based on peer-reviewed evidence. See link to Data Sources below. Everyone benefits from knowing this stuff. Please Share.
- CATEGORIES: Food Additives with E Numbers | Miscellaneous additives | Chemical Found in Air near CSG Operations | Chemicals used in hydraulic fracturing fluids | Household Toxin | Industrial/Workplace Toxin | Food Toxin | Synthetic Toxin | EAFUS (Everything Added to Food in the United States) | Inert Pesticide Ingredient USA - Food Use Permitted | A Hazardous Substance that may be found in the Australian Workplace
- SUBSTANCE LINEAGE: Organic Compounds | Hydrocarbons | Alkanes | Acyclic Alkanes | Acyclic Alkanes
- SYNONYMS: (CH3)2CH-CH3 | 1,1-Dimethylethane | 2-methyl-isobutane-Propane | 2-methyl-Propane | 2-Methylpropane | e943b | I-butane | Isobutane (NF) | Methylpropane | R-600a | Tert-butane | Trimethylmethane
- DESCRIPTION: E Number: E943b | Food Additives with E Numbers used in Australia, NZ, UK and the EU. Over 400 in total. | Substance has been approved in: Australia and NZ | EU and UK | | Miscellaneous additives | Has been used in CSG, Hydraulic Fracturing Operations (Fracking) as - Condensate water | Isobutane is a hydrocarbon and one of two isomers of butane. Butanes are highly flammable, colorless, odorless, easily liquefied gases. They are components of gasoline and can also be used as refrigerants and propellants in aerosol sprays. Butane gas is sold bottled as a fuel for cooking and camping and is also found in cigarette lighters. Butane is a simple asphyxiant and commonly used substance of abuse that is responsible for a large number of "solvent related" deaths. (L1283, L1284)
- COMMENTS: This Chemical is in the category of VOC and is found in Air near CSG Operations
From Safe Work Australia and the Hazardous Substances Information System (HSIS) in Australia:
Extremely flammable gas | | A Hazardous Substance that may be found in the Australian Workplace. Check with your employer or health and safety officer. Stay informed and become aware of the dangers that surround you. This chemical is included on the list of recognised hazardous chemicals from the Safe Work Australia - Hazardous Substances Information System (HSIS) that is based on the Globally Harmonised System of Classification and Labelling of Chemicals (GHS)
Work Health and Safety (WHS) Regulations are the basis for hazardous chemicals regulations in Commonwealth, State and Territory jurisdictions in Australia. Under the model WHS Regulations, manufacturers and importers of substances, mixtures and articles supplied for use in workplaces are required to determine whether they are hazardous to health and safety before supply. The model WHS Regulations mandate that the hazards of a chemical as determined by the Globally Harmonised System of Classification and Labelling of Chemicals (GHS) must be included in safety data sheets and on labels. There are transitional arrangements in place for moving to the GHS-based system.
The GHS Hazardous Chemical Information List contains chemicals classified by an authoritative source (such as the European Commission or NICNAS) in accordance with the Globally Harmonized System of Classification and Labelling of Chemicals (the GHS). This list contains the vast majority of chemicals currently in HSIS. This list and its detail are regularly updated by Work Safe Australia. The model Work Health and Safety (WHS) Regulations require chemicals to be classified in accordance with the Globally Harmonised System of Classification and Labelling of Chemicals (GHS). However transitional arrangements allow use of classification information in HSIS derived from the Approved Criteria until the 31 December 2016.
- FORMULA: C4H10
- DATA SOURCES: DATA SOURCES: ARTICLE 4 | T3DB | PubChem | Article-Colborn-2010 | FracFocus | EPA in USA | Article-Colborn-Air | FSANZ and FSA | EAFUS | EPA USA - Pesticide Inerts | Safe Work Australia - Hazardous Substances Information System (HSIS)
- LAST UPDATE: 28/04/2018
Mostly focused on Health Implications of Long Term Exposure to this substance
- SYMPTOMS: Inhalation of butane can cause euphoria, hallucinations, confusion, blurred vision, slurred speech, nausea, vomiting, coughing, sneezing, increased salivation, drowsiness, narcosis, asphyxia, cardiac arrhythmia, and frostbite. (L1283, L1284)
- POSSIBLE HEALTH CONSEQUENCES: Butane targets the central nervous system and cardiovascular system. Inhalation of butane can cause frostbite which can result in death from asphyxiation and ventricular fibrillation. (L1283, L1284) |
- ACTION OF TOXIN: Butane is a simple asphyxiant and causes toxicity by displacing oxygen. It also affects the central nervous system by enhancing glycine receptors and inhibiting nicotinic acetylcholine and N-methyl-d-aspartate (NMDA) receptors, resulting in anesthetic effects. (L1284, A352) | Butane binds to and enhances the activity of glycine receptors, resulting in anesthetic effects. (A352)
- TOXIN SITES OF ACTION IN CELL: "Membrane"
- Additional Exposure Routes: Butanes are components of gasoline and can also be used as refrigerants and propellants in aerosol sprays. Butane gas is sold bottled as a fuel for cooking and camping and is also found in cigarette lighters. Butane is a simple asphyxiant and commonly used substance of abuse that is responsible for a large number of "solvent related" deaths. (L1283, L1284)
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